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3.A.1.201.10
Mdr1; resistance to Cilofungin and other drugs (Lamping et al., 2010)

Accession Number:B0Y3B6
Protein Name:ABC multidrug transporter Mdr1
Length:1349
Molecular Weight:147724.00
Species:Aspergillus fumigatus (strain CEA10 / CBS 144.89 / FGSC A1163) [451804]
Number of TMSs:12
Substrate Cilofungin, drugs

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances

References (1)

[1] “Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.”  Fedorova N.D.et.al.   18404212

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MPAPETGASS REKSLEDLQV ATLEKGRSTS SSGADNEKPH DHHSLSDTIM APPDGKKKDH 
61:	GKAVDLNDDS LFAHLQEHEK EVLKRQLDAP SVKVSFFTLY RYASRKDILI ILVSAICAIA 
121:	AGAALPLFTI LFGSLASAFQ GISLGTMPYH EFYHKLTKNV LYFVYLGIAE FVTVYVSTVG 
181:	FIYTGEHLTQ KIRENYLEAI LRQNMAYFDK LGAGEVTTRI TADTNLIQDA ISEKVGLTLT 
241:	AFATFVTAFI VAYVKYWKLA LICTSTIVAL VMVMGGGSRF IVKYSKKSIE SYGAGGTVAE 
301:	EVISSIRNAT AFGTQDKLAK QYETHLAEAE KWGVKQQVIL GMMIGGMFGI MFSNYGLGFW 
361:	MGSRFVVGKE VNVGQVLTVL MSILIGSFSL GNVAPNGQAF TNGVAAAAKI YSTIDRRSPL 
421:	DPYSDEGKVL DHFEGNIEFR NVKHIYPSRP EVTVMEDVSL SMPAGKTTAL VGPSGSGKST 
481:	VVGLVERFYL PVGGQVLLDG HDIQTLNLRW LRQQISLVSQ EPVLFSTTIF RNIEHGLIGT 
541:	KFEHESKDKI RELVENAARM ANAHDFIMAL PEGYDTNVGQ RGFLLSGGQK QRIAIARAIV 
601:	SDPKILLLDE ATSALDTKSE GVVQAALDKA AEGRTTIVIA HRLSTIKTAH NIVAMVGGKI 
661:	AEQGTHDELV DRKGTYYKLV EAQRINEEKE AEALEADADM DADDFGQEGV TRIKTAVSSS 
721:	NSLDAVDEKA RLEMKRTGTQ KSVSSAVLSK KVPEQFEKYS LWTLVKFIGA FNRPELGYML 
781:	IGLTFSFLAG GGQPTQAFLY AKAISTLSLP ESMFHKLRHD ANFWSLMFFV VGIAQFISLS 
841:	INGTAFAICS ERLIRRARSQ AFRSILRQDI SFFDREENST GALTSFLSTE TKNLSGVSGV 
901:	TLGTIIMTST TLGAAMIIAL AIGWKLALVC ISVVPILLAC GFLRFYMLAQ FQQRSKSAYE 
961:	GSASYACEAT SAIRTVASLT REQDVWGVYH DQLQKQGRKS LISVLRSSLL YASSQALVFF 
1021:	CVALGFWYGG TLLGHHEYSI FRFFVCFSEI LFGAQSAGTV FSFAPDMGKA KNAAAQFKKL 
1081:	FDSKPTIDIW SDEGEKLESM EGEIEFRDVH FRYPTRPEQP VLRGLNLSVK PGQYIALVGP 
1141:	SGCGKSTTIA LLERFYDALA GGVFVDGKDI TKLNVNSYRS FLSLVSQEPT LYQGTIKENI 
1201:	LLGVDKDDVS EETLIKVCKD ANIYDFVMSL PEGFDTVVGS KGGMLSGGQK QRVAIARALL 
1261:	RDPKVLLLDE ATSALDSESE KVVQAALDAA ARGRTTIAVA HRLSTIQNAD IIYVFDQGKI 
1321:	VESGTHHELI RNKGRYYELV NLQSLGKTH