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3.A.1.201.11
Mdr1 azole resistance efflux pump (Lamping et al., 2010)

Accession Number:O43140
Protein Name:Multidrug resistance protein 1
Length:1408
Molecular Weight:152145.00
Species:Cryptococcus neoformans [5207]
Number of TMSs:12
Substrate Azoles

Cross database links:

eggNOG: fuNOG04952
Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances

References (1)

[1] “Cloning and characterization of CneMDR1: a Cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins.”  Thornewell S.J.et.al.   9409767

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSASPGLTAA AAGPDHLQAR RDEKVIDSEK DALAHDAHAV NSGIPYPTAT APNVGAPTVP 
61:	ISVGRVSSAA EGKISRSSIA ASSDTLRNSP LEKPISNAFS KSHPYKKSKF DFLKSRKKKE 
121:	EEERKNKEKE KEASVLPPVS FFALFRFAAP LEIIAMVLGL VLAVAAGSCQ PLMTLIFGRL 
181:	TTSFTNYAVI ANQISQGGLT PETSAALQAA KDDLKTQSGH NALYLMAIGI GMFLATWLYM 
241:	FIWNVTGELN SKRIRERYLA AVLRQEIAYF DDLGAGEVAT RIQTDCHLVQ EGTSEKVALV 
301:	FQYAGTFVCG FVLAFVRSPR LAGALVSILP VIMLCGGIMM TAMAKYGTAA LDHIAKAGSL 
361:	AEEVIGSIRT VQAFGKEKIL GDKFADHIEQ SKIVGRKGSI FEGFGLSIMF FVIYAAYALA 
421:	FFYGGILVSN GQADSGIVIN VFMSILIGSF SMAMLAPELA AVTKARGAAA KLFATIDRVP 
481:	AIDSASEEGF KPDGLRGEIS FENVKFHYPS RPSIPILKGF TTTFEAGKTF ALVGASGSGK 
541:	STVVSLIERF YDPVSGVVKL DGRDIRSLNL NWLRQQIGLV SQEPTLFGTT VRGNVEHGLI 
601:	GSRYENASLE EKFELVKKAC VDANAHNFIM KLPQGYDTMV GERGMLLSGG QKQRVAIARA 
661:	IVSDPRILLL DEATSALDTQ SEGIVQDALD KASRGRTTIT IAHRLSTIRD ADRIYVMGGG 
721:	EVLEQGSHND LLANENGPYA QLVNNQKLAQ EAAAEALQVD DDIEDPDDAV FIGGSSPMQE 
781:	KDKQLHRAVT GRSLASIAMD DIQAKRAEEV AGEDKIPSSF GLYARLLRMN SADKFIYIIA 
841:	FIAAICAGMV YPSLAILFGK ALSDFEIQDP AELRHALSRS ALWYFITALA AAFVIFFQSA 
901:	GFSRAGWDLN GVLRKKLFTA TLRHDIEWFD EERNSTGAVT SNLADQPQKV QGLFGPTLGT 
961:	VVQSCATLIG GCIIGLCYGP LLALIGIACI PILVSGGYIR LKVVVLKDQR MKKLHAASAH 
1021:	LASEAAGAVK TVASLTREKD VRRIYSEALK APMKLNFRTS IKSQCLFAAS QGLTFCIIAL 
1081:	VFYIGALWII DAKYSTASFY TVLNSIVFAS IQAGNVFTFV PDASKANSSA ASIFRSIDNE 
1141:	PAINAESNEG KVLDHKHVVG HVRIEGVHFR YPTRPGVRVL RNLTIDVPAG TYVALVGPSG 
1201:	CGKSTTIQML ERFYDPLAGR VTLDGIDIKE LNLASYRSQI SLVSQEPTLY AGTIRFNILL 
1261:	GANKPIEEVT QDEIDAACKD ANIYDFIVSL PDGFDTEVGG KGSQLSGGQK QRIAIARALI 
1321:	RNPKVLLLDE ATSALDSQSE KVVQEALDKA AKGRTTIAIA HRLSSIQHSD RIYYFSEGRV 
1381:	AEHGTHQELL AKKGGYYELV QMQNLSRQ