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3.A.1.201.12
California mussel ABCB/MDR multixenobiotic resistance efflux pump (Luckenbach and Epel, 2008).

Accession Number:B2WTH9
Protein Name:ABCB/p-glycoprotein-like protein
Length:1311
Molecular Weight:144505.00
Species:Mytilus californianus (California mussel) [6549]
Number of TMSs:13
Substrate xenobiotics

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances

References (1)

[1] “ABCB- and ABCC-type transporters confer multixenobiotic resistance and form an environment-tissue barrier in bivalve gills.”  Luckenbach T.et.al.   18401003

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSESEERKPL LADASDEQES YTDDKKTKDE EKKKPEGPPP ATLGQLFRYA TSVDTICILF 
61:	GSLFSLAHGA GWPVLSIVMG QMTDTFVAGP NGSLIPEGPN ATFNPNATTE SFEDKMTTYA 
121:	IYYLIIGGAV LFSGYLQIAC FMTACERQVN KIRKHFFRAI LRQEIGWFDK HQSGELTTRL 
181:	SDDLERVREG IGDKLSLLIQ FTAQFFAGFA IGFWKSWKMT LVMMSLTPVL AILAAYFSSL 
241:	MQNFAKREQA LYADAGSVAE EVISCMRTVV SFNGQKQEVK RYGKSLEETK QIGIKKSMVT 
301:	GLLLGSLYLV MFGDYALSFW YGNEQVKEYI TSMGAEGITP GTVLTVFFCV MIGSFSIGNA 
361:	APNIGSFVTA KGAAAVVYEI IDREPKIDAS SEKGQRPLSI QGALEFLGVN FTYPTREDVQ 
421:	VLTNFNLSIK PGQTVALVGS SGCGKSTIVN LIQRFYDPDA GQVLLDGNNI KDLNLNWLRQ 
481:	NIGVVSQEPV LFGCTIAENI RLGNPNATIT EIEQAAKQAN AHDFIKSLPQ SYNTLVGERG 
541:	AQLSGGQKQR VAIARALIRD PRILLLDEAT SALDSESENI VQEALEKARQ GRTTLVIAHR 
601:	LSTIQKADII YVVDKGEIIE QGTHGDLMDK QGLYHSLVTA QTLVNEDAGF QNQCEDVEFA 
661:	LEEEEEEEAV DAVPDQTVKR PRSRIKSTSS DDKSPQKLSR QMSRQLSRQM SGQPDGKDKA 
721:	DKEEEPEEQE EYEPPKYFRM IHENQPECGF IVLGIMASCV AGCTMPAFAI FFGEMIKVFI 
781:	ELGNNGLLWS MMFLALGGIN FLVYFVQASS FGISGEKLTQ RLRLGTFNAY MRQDIAFFDD 
841:	KFHSTGALTT RLATDASLVK TATGVRIGMV FQSLFGLVAA LVIAFYYGWA LALVVLGIVP 
901:	VIGFASSLQI KVLKGRHEED KGKLEDAGKT AAETIENIRT VQSLTTEKHF YHEYSHALVG 
961:	PLRSMIKQAH WYGIAFGLGQ GVIFMTYAGA FRFGAWQVEI GEMTADNVFK VFFAIAFTAM 
1021:	VIGQSSSFLP EYAKAKHAAG LIFKAFDTIP PIDIYSKRGT YLQKVDGLIQ FKEVNFCYPT 
1081:	RLEVKVLKGV NMKVEPGQTV ALVGQSGCGK STVISLLQRF YDPESGEIMI DGIDIKDLHL 
1141:	HKMRSFISVV SQEPILFNCS IRDNIAYGLE ETAGMDDIIT AARDANIHEF ITSQPMGYDT 
1201:	VVGEKGTQLS GGQKQRVAIA RALIRNPKIL LLDEATSALD SESEKLVQEA LDKAQEGRTC 
1261:	IVIAHRLSTI QNADVIFVMD NGTIVESGTH QTLLAKKGVY NSLVSAQQFI K