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3.A.1.201.13
Plasma membrane AbcB5. Mediates resistance of tumor cells to doxorubicin and other drugs including taxanes and anthracyclines (Kawanobe et al. 2012). Catalyzes efflux of rhodamine.

Accession Number:Q2M3G0
Protein Name:ATP-binding cassette sub-family B member 5
Length:812
Molecular Weight:89832.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate doxorubicin, Rhodamine, drugs

Cross database links:

Genevestigator: Q2M3G0
eggNOG: COG1132
Entrez Gene ID: 340273   
Pfam: PF00664    PF00005   
KEGG: hsa:340273   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0000139 C:Golgi membrane
GO:0005887 C:integral to plasma membrane
GO:0046581 C:intercellular canaliculus
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances
GO:0015562 F:efflux transmembrane transporter activity
GO:0042391 P:regulation of membrane potential

References (8)

[1] “Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter.”  Frank N.Y.et.al.   12960149
[2] “Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.”  Chen K.G.et.al.   15760339
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance.”  Huang Y.et.al.   15205344
[6] “ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.”  Frank N.Y.et.al.   15899824
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[8] “Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.”  Jones S.et.al.   18772397

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVDENDIRAL NVRHYRDHIG VVSQEPVLFG TTISNNIKYG RDDVTDEEME RAAREANAYD 
61:	FIMEFPNKFN TLVGEKGAQM SGGQKQRIAI ARALVRNPKI LILDEATSAL DSESKSAVQA 
121:	ALEKASKGRT TIVVAHRLST IRSADLIVTL KDGMLAEKGA HAELMAKRGL YYSLVMSQDI 
181:	KKADEQMESM TYSTERKTNS LPLHSVKSIK SDFIDKAEES TQSKEISLPE VSLLKILKLN 
241:	KPEWPFVVLG TLASVLNGTV HPVFSIIFAK IITMFGNNDK TTLKHDAEIY SMIFVILGVI 
301:	CFVSYFMQGL FYGRAGEILT MRLRHLAFKA MLYQDIAWFD EKENSTGGLT TILAIDIAQI 
361:	QGATGSRIGV LTQNATNMGL SVIISFIYGW EMTFLILSIA PVLAVTGMIE TAAMTGFANK 
421:	DKQELKHAGK IATEALENIR TIVSLTREKA FEQMYEEMLQ TQHRNTSKKA QIIGSCYAFS 
481:	HAFIYFAYAA GFRFGAYLIQ AGRMTPEGMF IVFTAIAYGA MAIGETLVLA PEYSKAKSGA 
541:	AHLFALLEKK PNIDSRSQEG KKPDTCEGNL EFREVSFFYP CRPDVFILRG LSLSIERGKT 
601:	VAFVGSSGCG KSTSVQLLQR LYDPVQGQVL FDGVDAKELN VQWLRSQIAI VPQEPVLFNC 
661:	SIAENIAYGD NSRVVPLDEI KEAANAANIH SFIEGLPEKY NTQVGLKGAQ LSGGQKQRLA 
721:	IARALLQKPK ILLLDEATSA LDNDSEKVVQ HALDKARTGR TCLVVTHRLS AIQNADLIVV 
781:	LHNGKIKEQG THQELLRNRD IYFKLVNAQS VQ