TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.201.15
MDR efflux pump, ABCB1a.  Exports canonical MDR susbtrates such as calcein-AM, bodipy-verapamil, bodipy-vinblastine and mitoxantrone (Gokirmak et al. 2012).

Accession Number:Q3T7C8
Protein Name:Egg permeability glycoprotein
Length:1329
Molecular Weight:144825.00
Species:Strongylocentrotus purpuratus (Purple sea urchin) [7668]
Number of TMSs:12
Substrate drugs, Calcein-AM, Bodipy-verapamil, Bodipy-vinblastine, mitoxantrone

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVEGDPPAVG FSNGNGTVQM NGNGASFDGP AVIDVSPVHE DAPSAKHARD SPPPAYNDVD 
61:	GTKEQENGGS VEGEGGEKEE KKETKVVGTF EVFRFATGLD VVFILLALVI SLCHGVALPA 
121:	VLLLFGEVTD SFITTASVNV TDNLAAFEES VDSIITFSIY YSYLGCGVLA LAYFQVVLWD 
181:	VAAERQIHKV RLRFFHAILR QEIAWFDVHK GGELNTRLAD DIDKIRNGIG DKLGIMLQYT 
241:	ATFVAGITIG FVKSWKLTLV ILAVSLILIV PLVGSTSVII QRMTKQALDA YAKAGAIAGE 
301:	VFSGIRTVVA FNGEEKEMVR YSSNLDQAKS KTVKKDFATL LAQGFLFFSM FSSYAIAFWY 
361:	GTVLYLDNEI TPGDILTTFL AVLFGAFAIG QAGPNYSDFT TARAAASSIW EVIDQIPTID 
421:	CFSTDGKKEK ITGQVTFEGV HFSYPSRASV KVLNGINLKV DVGKTVAMVG SSGCGKSTCI 
481:	QLIQRFYDVA EGSIKIDGID IRDLNVSWLR DHIGVVSQEP ILFATTIEEN IRYGRLDVTQ 
541:	VEIEKAAEEA NAHEFISKLP EGYSTLVGER GAQLSGGQKQ RIAIARALVR NPTILLLDEA 
601:	TSALDTESEA TVQLALEKAQ HGRTTLVIAH RLSTIFNSDL ICAFKEGIIS EQGTHEELMK 
661:	NEGGVYHTLV MKQGMKKEEE EEKKENEVPL DDDDDEEDDS QGEKVYRAGS GKKKLTRVLS 
721:	RTQSQMSGDE EKQDEDEYEK ELEKHFSMMR VWKLNTPECG FILLGCIGAA INGAVQPGFA 
781:	VVFSKILGAY SITDRAALFD EVTIYCVLFA ALGLLSLLAS IIQGVGFGKS GGELTLRLRN 
841:	MMFRAILRQN ISFFDDKRNG TGALTTKLAT DVSLIQGVTG VRLGMIFEVL FNIGVGIVIS 
901:	FVYSWQIACL LLFAFLPILS LAGMIGWKIL QGNSIGTAGS QAEVGKLVSE CIENIRTVQS 
961:	LNRGQTFHLK YCELQNPPYK QGIKGAFAAG LAFGFSQATI FFAYSATFRL GAHLVGTGDL 
1021:	TFPDVFLSFS ALMFGAFGLG RAAGSVPDFS KAKVATGELF YLVDRSPDID TFSDDGEKPA 
1081:	SYGGSVSLNN VRFRYPTRPD VPVLRGLSVS VDPGETLALV GSSGCGKSTT IQLMERFYDP 
1141:	HSGTVMFDSH DASLLNTRWQ RAQVGLVSQE PCLFDMSIAE NIKYGDNSRE VSIEDCIEAA 
1201:	KKSNIHDFVD SLPMKYDTNV GSKGTQLSGG QKQRIAIARA LVRNPKVLLL DEATSALDTE 
1261:	SERVVQDALD EAKKGRTCIT IAHRLSTIHN AEKIAVIREG KLAEFGKHEE LMAMKQQYYS 
1321:	LYTAQSMQH