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3.A.1.201.16
MDR efflux pump, ABCB4a.  Exports canonical MDR susbtrates such as calcein-AM, bodipy-verapamil, bodipy-vinblastine and mitoxantrone (Gokirmak et al. 2012).

Accession Number:I0DHH7
Protein Name:ATP-binding cassette transporter subfamily B member 4a
Length:1298
Molecular Weight:141531.00
Species:Strongylocentrotus purpuratus (Purple sea urchin) [7668]
Number of TMSs:12
Substrate Calcein-AM, Bodipy-verapamil, Bodipy-vinblastine, mitoxantrone

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVVENGHTKG LDDDGTEVAF KNGNYGATNG KDTANGTIKG EEKSDEKENE KEEEKPQVPF 
61:	TRLFRYATGL DGLFMFIGCF AAVCHGCAWP ALNIVFGGLI DEFVDFDKLN TTNTTDFTAT 
121:	LPPGLDPAKE FDNQMQMYAV IFTYIGIGVM VMAYLQSSMW TLAGERQIYK IRQAFFNAIL 
181:	HQEIQWFDVH KSGELTSRLA DDMERVKDGL GDKIALCLQS LSLFLAGFGI AFWKSWELTL 
241:	VLLSTTPLLA AAGGFMAYFL TSFAKLEQES YAQAGSVAEE VLSCVRTVIA FGGEQKEVTR 
301:	YEKELKEARD VGVKKGVTSG VGMGITMFIM FGSYALAFWY GPKLVADGRI TGGDVMIVFF 
361:	SVMIGSFSIG NISPSMTAIT AARGAAVTLF DVIDARPAID TRSKKGIVPA EMTGNIDFQG 
421:	VEFSYPTRDD VPVLKGVDLS IRKGQTVALV GSSGCGKSTT INLLLRFYEK LGGNILIDGH 
481:	KIEELNLHWL RRHMGVVSQE PVLFNCSIET NISYGRDGVT KEEIINAAKM ANAHDFISKL 
541:	PKGYDTMVGE RGAQLSGGQK QRVAIARALV RNPPILLLDE ATSALDRESE KVVQQALDKA 
601:	SEGRTTLVIA HRLTTIRNAD VIYAFEDGRV VEFGDHAELM KRDGVYKQLV TLQTLDGAGE 
661:	ESTSSSKEVV RKESIKRLPS RQMSRQISRQ MSNGSGKMEE SVEVKEEVEE EEVEERGYLE 
721:	ILKMNKPEWL YIVVGCVFAG ILGVAMPAFA ILFSEVIAIF SLPADELREE SVFWALMFLA 
781:	LGGAFFVSNS VTGYCFSISG EELTLRLRKK AFWTILRQDC AYFDQPSHST GALATRLSSD 
841:	ASNVKGATGM RISTIVQAIV TMVVAITIGF VFGWKLALLI FGCLPVLALS GALEMKILQG 
901:	GHEKDAALIE EAGKIAAEAI ENVRTVASLN LEDRMIANYT EQLQNPYRQG KINSQINGLA 
961:	FAVSQAMIFF IYAASFRLGG YLVSIGDMTV DEVFKVVFGV AFAGISVGQS LAFLPDYAKA 
1021:	RHSADLMLHL FSIKPLIDNY STDGAQPQKV DGKIEYSGLK FSYPTRPDVT VLKGLSLTIK 
1081:	PGQTVALVGE SGCGKSTLVS LLERFYDPAQ GSVALDGTPV KDINIQWLRA NMAIVSQEPI 
1141:	LFACSIGDNI QYGVETPMEQ AAIENVAKMA NIHDFIASLP LGYDTLVGEK GAQLSGGQKQ 
1201:	RVAIARAMAR NPRILLLDEA TSALDTESEK VVQAALDNAM QGRTSIVIAH RLSTIQNADT 
1261:	IAVIREGVVV ESGSHQELLQ SKGHYFTLTG GKIDVESE