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3.A.1.201.20
12 TMS multidrug resistance transprter of 1318 aas, AbcB15 (Xiong et al. 2010) is the probable exporter of dichlorodiphenyltrichloroethane (DDT). Expression is induced by treatment with DDT, and this transporter appears to be responsible for DDT tolerance by pumping it out of the cell (Ning et al. 2014).

Accession Number:I7LXH0
Protein Name:ABC transporter family protein
Length:1334
Molecular Weight:150120.00
Species:Tetrahymena thermophila (strain SB210) [312017]
Number of TMSs:9
Substrate drugs, Dichlorodiphenyltrichloroethane

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEKSLQNLE KPTQNYEDQE VADASKTDII LVVLGSLASV INGCLQPLFG LLFGEMAQKF 
61:	SPGYSADAVV DNCRTIALWF VGIGASNFFL VDNFDLIIMV EIRGQNMPTS FNNFVNVGQR 
121:	QAIKFRLEYF KSLLKQEVGY FDQIQANELS SKVSTECFKI QSALGEKTCI FIYSLSMFIG 
181:	SLIIAFIRGW QIALVAIAVT PLIASAGYFD QWVSEGIVKK TSSAYSSAGG ISEQAISAIR 
241:	TVKGLNGQDF EQNKYQSMIK KAFQVSLKFS IYEGVGLGLQ NMMFFFDFAL TFWVGSKFIE 
301:	DEVYNHNQGR SYNFSDVLTA FLAIMMSSFE LGQAMNSIKA FTQARQAGFN MFQILNRKSK 
361:	VDLNENGIDL TKKQINGEIK FENVDFSYPT HLDTKILKNL NISIQPHKKT AFVGESGRMY 
421:	LNFIFFKISG KSTIVQLIER FYDPQFGNIY LDGVNLKDFK LTSLRQSIGY VGQEPVLFAT 
481:	TIRENLLYGK RDATEEQMIE ALKQANAWQF IEKLEKGLDT YVGTSGAQFS GGQKQRISIA 
541:	RAILKNPKIL LLDEATSALD RKNEAQIQST LDSVSKGLTT IVVAHRLSTI QNSDEIIVLD 
601:	KGVVVERGTH DDLLKNNGAY FKFVEKQKII EKEQEKQAAH NNKTLCLLGE TQSRLASQSS 
661:	QTLNTEQEFL MKQESQNQNC QKLIQQFQNL NNIKEEDDDN DDEEAQNKAI RSSFSSQTQN 
721:	TPKQIEIVEQ NIIDLQNIQN TNVKQAQEKT NDQGIMKRLF SYNEKQTINY VLGFLFAIGN 
781:	GVCYPFSGYV LGKISDVLLD RTRSDFREQS NLQSLYFLIL GLAQLLTCTF QFYFFSRVAE 
841:	QLTFKLRKDL FQKYLKMPIS WFDHPHNTPG SLTQKLSTDC QAVNNMTSST LGIQLSNVSS 
901:	LVSALALAFS ADWRTTLVGL SLMPLMVLSQ AWYMSRMEGF GEKTDAAFRD STNMINEAAC 
961:	NIRTVTSFGN NQQLVQNFTQ ILDKNIKEIK KSALEAGLAI ACTNFILFAI YGTIFYAGST 
1021:	FHRDYDLSIV DMFISIQCLM FAAIGIGSNS HYLGDVGTSQ NAAKGIFQVL DSVDENQLNI 
1081:	LNFDNQDIHG EIQFKNVTFK YPQRDQIILK DVSFTIPAGQ KVAFVGPSGA GKSSIIQLIQ 
1141:	RFYDNYQGEI LLDGVDIKNY DLLKYRSKFG VVSQEPTLFT GTIKENIIYN TENVNEQQIE 
1201:	SITKQVNAYD FITNYSKNGV NGFDRQVGLK GNQLSGGQKQ RIAICRAMIK QPKIMLLDEA 
1261:	TSALDSQNEK IVQESLNEAM KQKTSICVAH RISTIKDSDM IYVMENGNIV EQGKYDQLMN 
1321:	LKNNFYKLQL GSSQ