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3.A.1.201.26
ABC multidrug exporter, MDR1 of 1341 aas, 12 TMSs and two ATPase domains in an MCMC arrangement.  Miltefosine (hexadecylphosphocholine), the first orally available drug available to treat leishmaniasis, is pumped out of the parasite by MDR1, a P-glycoprotein-like transporter. Overexpression of LtrMDR1 increases miltefosine efflux, leading to a decrease in drug accumulation in the parasites and resistance (Pérez-Victoria et al. 2006).

Accession Number:Q4Q3A6
Protein Name:p-glycoprotein
Length:1341
Molecular Weight:146912.00
Species:Leishmania major [5664]
Number of TMSs:11
Substrate Miltefosine (hexadecylphosphocholine), multiple drugs

Cross database links:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPEGSERGAS AKGGSVFEWE DRQGSFSPHQ PIAEGLVERG DCCEHNDYRY GPAPQSRELI 
61:	DMSHTYDVYV DEGKLALVNK PADQSDSTHG GSGYDSRNPL FSAEEEVKRA AVNESVSPIA 
121:	IFRYADTTDR ALMIIGTIFA ICSGAGMPFF SFIFGRIAMD LMSGVGSVEL SAAKMSLIMV 
181:	YVGIGMFVTC GGHVLCWTVT ASRQEGRIRL NFFRAVLRQD IGWHDEHSPG ELTARMTGDT 
241:	HVIQNGINDK LSQGIMNGAM GIIGYIAGFA FSWELTLVMV GMMPFIIVMT AIIGNIVSKM 
301:	TESSLKHFAK AGSLATEVME NIRTVQVFGR EDYELQRFAE AVLHAQDRGI RKEFAGNLSA 
361:	AVIMALVYLS YTIAFFFGSY LVEWGRRDMA DIISTFLAVL MGSLGLGFVA PSVTAFTESR 
421:	AAAYAIFKAI DRVPPVDIDA DGVPVTGFEQ SIEFRNVRFS YPTRPDMILF RDLNLTIRCG 
481:	QKIAFSGSSG CGKSSMLGLI QRFYDPAGGT VLCDGVDMRE LCLRDWRDQI GIVSQEPNLF 
541:	AGTMMENVRV GKPNATEEEV IEACRQANVH DTIMSLPDQY NTPVGAVGSQ LSGGQKQRIA 
601:	IARALVKRPP ILLLDEATSA LDRKSEMEVQ RSLDRLMEKG GMTVIVIAHR LATIRNVDCI 
661:	YYVKYDGAEG SKITESGTFD ELMELGGEFA AMARIQGVST GDVRSGARGQ DCGKANDFLN 
721:	VILDEAALAH LDEEAPRTAR QKVPIEELAK WEVNDVNVGF RRLMGMNKDK SWAVALGILG 
781:	SAVGGAARPT SSILMGYMLR VLGEYSVNKN VEQLRSGTNL YAPLFILFSF ATFLGWVLHG 
841:	FYGYAGEHLT TKIRVLLFRQ IMRQDMNFFD IPGRDAGTLA GMLSGDCEAV HQLWGPSIGL 
901:	KVQTVCIVAS GVVVSFIYQW KLALVALACM PLLIGCSLAE RTMMNGYTKS KEGDTSDTIV 
961:	TEALSSVRTV TSFNMKADRV EAFEATLRVE TPRSVKKGII AGSIYGATQF IYYSAYALCF 
1021:	WYGSKLIDRG EAQFTDVMIA SMSILLGAQN AGEAGAFATK LADAERSAKR VFSVIDRVPD 
1081:	VDIEQPGDKD LGKGCDVDFR KVQFIYSARP KQVVLASVNL RFGDGTANGL MGQTGCGKST 
1141:	IIQMLARFYD RRSGLICVNG KDLSSLDIAE WRRNISVVLQ EPNLFSGTVR ENIRYAREDA 
1201:	TDDEVEEAAR LAQIHWEIVK WPDGYNTEVG YKGSALSGGQ KQRVAIARGL LRRPKLLLLD 
1261:	EATSALDNVT EAKVQEGINA YQAKYGVTSV SIAHRLTTIR HCDQIILLDS GHIIEQGSHE 
1321:	ELMALGGEYM MRYDLYTGAS S