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3.A.1.201.27
Multidrug resistance exporter of 1331 aas and 12 TMSs, TratrD or MDR2. Almost identical throughout must of its length to F2PRR1 from T equinum of 1235 aas and 12 TMSs (Martins et al. 2016). Displays increased levels of transcription of the TruMDR2 gene when mycelia were exposed to acriflavine, benomyl, ethidium bromide, ketoconazole, chloramphenicol, griseofulvin, fluconazole, imazalil, itraconazole, methotrexate, 4-nitroquinoline N-oxide (4NQO) or tioconazole. Disruption of the TruMDR2 gene rendered the mutant more sensitive to terbinafine, 4NQO and ethidium bromide than the control strain, suggesting that this transporter plays a role in modulating drug susceptibility in T. rubrum (Fachin et al. 2006).

Accession Number:Q9HGT5
Protein Name:Multidrug resistance protein MDR
Length:1331
Molecular Weight:145284.00
Species:Trichophyton rubrum (Athlete's foot fungus) [5551]
Number of TMSs:12
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVEVSEKPNT QDDGVSKQEN RNPASSSSST SDKEKVAKKG NSDATKSSTP EDLDAQLAHL 
61:	PEHEREILKQ QLFIPDAKAT YGTLFRYATR NDMIFLAIVS LASIAAGAAL PLFTVLFGSL 
121:	AGTFRDIALH RITYDEFNSI LTRNSLYFVY LGIAQFILLY VSTVGFIYVG EHITQKIRAK 
181:	YLHAILRQNI GFFDKLGAGE VTTRITADTN LIQDGISEKV GLTLTALSTF FSAFIIGYVR 
241:	YWKLALICSS TIVAMILVMG GISRFVVKSG RMTLVSYGEG GTVAEEVISS IRNATAFGTQ 
301:	EKLARQYEVH LKEARKWGRR LQMMLGIMFG SMMAIMYSNY GLGFWMGSRF LVGGETDLSA 
361:	IVNILLAIVI GSFSIGNVAP NTQAFASAIS AGAKIFSTID RVSAIDPGSD EGDTIENVEG 
421:	TIEFRGIKHI YPSRPEVVVM EDINLVVPKG KTTALVGPSG SGKSTVVGLL ERFYNPVSGS 
481:	VLLDGRDIKT LNLRWLRQQI SLVSQEPTLF GTTIFENIRL GLIGSPMENE SEEQIKERIV 
541:	SAAKEANAHD FIMGLPDGYA TDVGQRGFLL SGGQKQRIAI ARAIVSDPKI LLLDEATSAL 
601:	DTKSEGVVQA ALDAASRGRT TIVIAHRLST IKSADNIVVI VGGRIAEQGT HDELVDKKGT 
661:	YLQLVEAQKI NEERGEESED EAVLEKEKEI SRQISVPAKS VNSGKYPDED VEANLGRIDT 
721:	KKSLSSVILS QKRSQEKETE YSLGTLIRFI AGFNKPERLI MLCGFFFAVL SGAGQPVQSV 
781:	FFAKGITTLS LPPSLYGKLR EDANFWSLMF LMLGLVQLVT QSAQGVIFAI CSESLIYRAR 
841:	SKSFRAMLRQ DIAFFDLPEN STGALTSFLS TETKHLSGVS GATLGTILMV STTLIVALTV 
901:	ALAFGWKLAL VCISTVPVLL LCGFYRFWIL AQFQTRAKKA YESSASYACE ATSSIRTVAS 
961:	LTREQGVMEI YEGQLNDQAK KSLRSVAKSS LLYAASQSFS FFCLALGFWY GGGLLGKGEY 
1021:	NAFQFFLCIS CVIFGSQSAG IVFSFSPDMG KAKSAAADFK RLFDRVPTID IESTDGEKLE 
1081:	TVEGTIEFRD VHFRYPTRPE QPVLRGLNLT VKPGQYIALV GPSGCGKSTT IALVERFYDT 
1141:	LSGGVYIDGK DISRLNVNSY RSHLALVSQE PTLYQGTIRD NVLLGVDRDD VPDEQVFAAC 
1201:	KAANIYDFIM SLPDGFGTVV GSKGSMLSGG QKQRIAIARA LIRDPKVLLL DEATSALDSE 
1261:	SEKVVQAALD AAAKGRTTIA VAHRLSTIQK ADIIYVFDQG RIVESGTHHE LLQNKGRYYE 
1321:	LVHMQSLEKT Q