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3.A.1.201.31
Permeability glycoprotein, P-Glycoprotein 65, P-GP65, MDR65 of 1302 aas and 12 TMSs. a detoxification efflux pump transporting various lipophilic xenobiotics out of the cells. Exports Polycyclic aromatic hydrocarbons (PAHs), ubiquitous environmental contaminants (Vaché et al. 2006). When flies are exposed to benzo[a]pyrene or to ambient air polluted by higher or lower PAH concentrations, P-gp expression was induced (Vaché et al. 2006).

Accession Number:Q00748
Protein Name:Multidrug resistance protein homolog 65
Length:1302
Molecular Weight:143784.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERDEVSTSS SEGKSQEEAP MAEGLEPTEP IAFLKLFRFS TYGEIGWLFF GFIMCCIKAL 
61:	TLPAVVIIYS EFTSMLVDRA MQFGTSSNVH ALPLFGGGKT LTNASREENN EALYDDSISY 
121:	GILLTIASVV MFISGIFSVD VFNMVALRQV TRMRIKLFSS VIRQDIGWHD LASKQNFTQS 
181:	MVDDVEKIRD GISEKVGHFV YLVVGFIITV AISFSYGWKL TLAVSSYIPL VILLNYYVAK 
241:	FQGKLTAREQ ESYAGAGNLA EEILSSIRTV VSFGGEKSEV QRYENFLVPA RKASQWKGAF 
301:	SGLSDAVLKS MLYLSCAGAF WYGVNLIIDD RNVENKEYTP AILMIAFFGI IVGADNIART 
361:	APFLESFATA RGCATNLFKV IDLTSKIDPL STDGKLLNYG LRGDVEFQDV FFRYPSRPEV 
421:	IVHRGLNIRI RAGQTVALVG SSGCGKSTCV QLLQRFYDPV FGSVLLDDLD IRKYNIQWLR 
481:	SNIAVVGQEP VLFLGTIAQN ISYGKPGATQ KEIEAAATQA GAHEFITNLP ESYRSMIGER 
541:	GSQLSGGQKQ RIAIARALIQ NPKILLLDEA TSALDYQSEK QVQQALDLAS KGRTTIVVSH 
601:	RLSAIRGADK IVFIHDGKVL EEGSHDDLMA LEGAYYNMVR AGDINMPDEV EKEDSIEDTK 
661:	QKSLALFEKS FETSPLNFEK GQKNSVQFEE PIIKALIKDT NAQSAEAPPE KPNFFRTFSR 
721:	ILQLAKQEWC YLILGTISAV AVGFLYPAFA VIFGEFYAAL AEKDPEDALR RTAVLSWACL 
781:	GLAFLTGLVC FLQTYLFNYA GIWLTTRMRA MTFNAMVNQE VGWFDDENNS VGALSARLSG 
841:	EAVDIQGAIG YPLSGMIQAL SNFISSVSVA MYYNWKLALL CLANCPIIVG SVILEAKMMS 
901:	NAVVREKQVI EEACRIATES ITNIRTVAGL RREADVIREY TEEIQRVEVL IRQKLRWRGV 
961:	LNSTMQASAF FAYAVALCYG GVLVSEGQLP FQDIIKVSET LLYGSMMLAQ SLAFTPAFSA 
1021:	ALIAGHRLFQ ILDRKPKIQS PMGTIKNTLA KQLNLFEGVR YRGIQFRYPT RPDAKILNGL 
1081:	DLEVLKGQTV ALVGHSGCGK STCVQLLQRY YDPDEGTIHI DHDDIQHDLT LDGVRTKLGI 
1141:	VSQEPTLFER SIAENIAYGD NRRSVSMVEI IAAAKSANAH SFIISLPNGY DTRMGARGTQ 
1201:	LSGGQKQRIA IARALVRNPK ILLLDEATSA LDLQSEQLVQ QALDTACSGR TCIVIAHRLS 
1261:	TVQNADVICV IQNGQVVEQG NHMQLISQGG IYAKLHKTQK DH