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3.A.1.201.32
ABCB4 of 1286 aas and an MCMC domain arrangememnt.  The transport substrates are auxins (Lefèvre and Boutry 2018).

Accession Number:O80725
Protein Name:Multidrug resistance protein 4 aka Pgp4
Length:1286
Molecular Weight:139028.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: O80725
eggNOG: KOG0055
HEGENOM: HBG758042
RefSeq: NP_182223.1   
Entrez Gene ID: 819314   
Pfam: PF00664    PF00005   
KEGG: ath:AT2G47000   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0010315 P:auxin efflux
GO:0010540 P:basipetal auxin transport
GO:0009630 P:gravitropism
GO:0009735 P:response to cytokinin stimulus
GO:0048767 P:root hair elongation
GO:0055085 P:transmembrane transport

References (8)

[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[2] “PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots.”  Terasaka K.et.al.   16243904
[3] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[4] “Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.”  Nuehse T.S.et.al.   14506206
[5] “Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database.”  Nuehse T.S.et.al.   15308754
[6] “MDR-like ABC transporter AtPGP4 is involved in auxin-mediated lateral root and root hair development.”  Santelia D.et.al.   16198350
[7] “Quantitative phosphoproteomic analysis of plasma membrane proteins reveals regulatory mechanisms of plant innate immune responses.”  Nuehse T.S.et.al.   17651370
[8] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MASESGLNGD PNILEEVSET KRDKEEEEEV KKTEKKDEEH EKTKTVPFYK LFAFADSFDF 
61:	LLMILGTLGS IGNGLGFPLM TLLFGDLIDA FGENQTNTTD KVSKVALKFV WLGIGTFAAA 
121:	FLQLSGWMIS GERQAARIRS LYLKTILRQD IAFFDIDTNT GEVVGRMSGD TVLIQDAMGE 
181:	KVGKAIQLLA TFVGGFVIAF VRGWLLTLVM LSSIPLLVMA GALLAIVIAK TASRGQTAYA 
241:	KAATVVEQTI GSIRTVASFT GEKQAISNYN KHLVTAYKAG VIEGGSTGLG LGTLFLVVFC 
301:	SYALAVWYGG KLILDKGYTG GQVLNIIIAV LTGSMSLGQT SPCLSAFAAG QAAAYKMFET 
361:	IERRPNIDSY STNGKVLDDI KGDIELKDVY FTYPARPDEQ IFRGFSLFIS SGTTVALVGQ 
421:	SGSGKSTVVS LIERFYDPQA GDVLIDGINL KEFQLKWIRS KIGLVSQEPV LFTASIKDNI 
481:	AYGKEDATTE EIKAAAELAN ASKFVDKLPQ GLDTMVGEHG TQLSGGQKQR IAVARAILKD 
541:	PRILLLDEAT SALDAESERV VQEALDRIMV NRTTVVVAHR LSTVRNADMI AVIHQGKIVE 
601:	KGSHTELLKD PEGAYSQLIR LQEEKKSDEN AAEEQKMSSI ESFKQSSLRK SSLGRSLSKG 
661:	GSSRGNSSRH SFNMFGFPAG IDGNVVQDQE EDDTTQPKTE PKKVSIFRIA ALNKPEIPVL 
721:	ILGSISAAAN GVILPIFGIL ISSVIKAFFQ PPKKLKEDTS FWAIIFMVLG FASIIAYPAQ 
781:	TFFFAIAGCK LVQRIRSMCF EKVVHMEVGW FDEPENSSGT IGARLSADAA TIRGLVGDSL 
841:	AQTVQNLSSI LAGLIIAFLA CWQLAFVVLA MLPLIALNGF LYMKFMKGFS ADAKKMYGEA 
901:	SQVANDAVGS IRTVASFCAE DKVMNMYSKK CEGPMKNGIR QGIVSGIGFG FSFFVLFSSY 
961:	AASFYVGARL VDDGKTTFDS VFRVFFALTM AAMAISQSSS LSPDSSKADV AAASIFAIMD 
1021:	RESKIDPSVE SGRVLDNVKG DIELRHVSFK YPARPDVQIF QDLCLSIRAG KTVALVGESG 
1081:	SGKSTVIALL QRFYDPDSGE ITLDGVEIKS LRLKWLRQQT GLVSQEPILF NETIRANIAY 
1141:	GKGGDASESE IVSSAELSNA HGFISGLQQG YDTMVGERGI QLSGGQKQRV AIARAIVKDP 
1201:	KVLLLDEATS ALDAESERVV QDALDRVMVN RTTIVVAHRL STIKNADVIA VVKNGVIVEK 
1261:	GKHDTLINIK DGVYASLVQL HLTAAS