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3.A.1.201.35
P-glycoprotein, Pgp, ABCB1, of 1241 aas and 12 TMSs with a domain order MCMC.  Exports geraniol and other monoterpenes. Demissie et al. 2018 reported two structures of this homodimeric P-glycoprotein: an outward-facing conformational state with bound nucleotide and an inward-facing apo state, at resolutions of 1.9 Å and 3.0 Å, respectively. Features that could be clearly visualized include ATP binding with octahedral coordination of Mg2+; an inner chamber that significantly changes in volume with the aid of tight connections among transmembrane helices (TMSs) 1, 3, and 6; a glutamate-arginine interaction that stabilizes the outward-facing conformation; and extensive interactions between TMS1 and TMS3, a property that distinguishes multidrug transporters from floppases. These structural elements were proposed to participate in the mechanism of the transporter (Demissie et al. 2018).

Accession Number:AIX02990
Protein Name:AIX02990.1 ATP binding cassette transporter subfamily B1 [Lavandula angustifolia subsp. angustifolia]
Length:1242
Molecular Weight:
Species:Lavandula angustifolia subsp. angustifolia [1211581]
Number of TMSs:12
Substrate

Cross database links:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSHQSASGTA SSLSMEDDEK KQHSAEKKTV GLAKMFSFAD RTDYLLMFVG SIGACVHGAS 
61:	VPVFFIFFGK MINIIGLAYL FPQQASHKIA TRWLVGMHSG ERQAAKMRMA YLRSMLNQDI 
121:	SIFDTESSTG EVISAITTDI IVVQDAISEK VGKFLHYISR FVAGFAIGFI RVWQISLVTL 
181:	SIVPLIAIAG GIYAYVATGL IARVRKSYVK AGEIAEEVIG NVRTVQAFAG EEKAVKSYTT 
241:	SLLETYKYGR KAGLAKGLGL GTLHCVLFLS WALLVWYTSI VVHKNIANGG ESFTTMLNVV 
301:	IAGLSLGQAA PDITAFIRAK AAAYPIFEMI ERNTVSKTSR SSGDGKRLSK VEGHIKFKNV 
361:	RFSYPSRPDV LIFSKLSLDI PLGKIVALVG GSGSGKSTVI SLIERFYEPL SGQVLLDGTD 
421:	IRELDLKWLR QQIGLVNQEP ALFATTIRDN ILYGKKDASN EEITRAAKLS EAINFINNLP 
481:	ERFETQVGER GIQLSGGQKQ RIAISRAIVK NPSILLLDEA TSALDAESEK SVQEALDRVM 
541:	VGRTTIIVAH RLSTIRNADM IAVVQNGAIV ETGSHEDLIS RPNSAYASLV QLQEAASLTR 
601:	LPSHGSAMGR PLSIRYSREG SIRYSRELSR TTRSLGASFR SEKSLSRFGG DGGESIGKPV 
661:	KVSSGRLYSM VRPDWFYGIS GTICAFIAGA QFPLFAVGVT QALVSYYMDW DTTCREVKKI 
721:	AFLFTGGAAL TVIVHAITHL SFGIMGERLT LRVREKMFTA MLRNEIGWFD DVNNNSAMLA 
781:	SRLASDATLL KTVVVDHSTI LLQNVGLVVT SFVIAFMLNW RLTLVVIATY PLIISGHISE 
841:	KLFMKGYGLD LNKAYLKANM LAGEAVSNIR TVAAFCSEEK VLDLYARELI EPSKTSFRRG 
901:	QAAGIFYGVS QFFIFSSYAL ALWYGSTLME KGLSGFKSVM KSFMVLIVTA LAMGETLAMA 
961:	PDLLKGNRMV ASVFEVLDRR TEIVGDVGEE VSRVEGTIEI KDVEFSYPSR PNVLIFKDFN 
1021:	VRVHSGRSIA LVGQSGSGKS SVIALILRFY DPISGKVVID GKDIKKLKVK SVRKHIGLVQ 
1081:	QEPALFATSI YENILYGKEG ATEAEIVEAA KLANAHSFIS SLPEGYSTRV GERGVQLSGG 
1141:	QKQRVAIARA ILKNPSILLL DEATSALDVE SERVVQQALD RLMKNRTTVM VAHRLSTIKN 
1201:	ADQISVLQDG KIIEQGTHSS LVENKDGAYY KLINLQRQQE I