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3.A.1.201.39
Multidrug resistance-1, Mdr1, of 1464 aas and 12 TMSs in a 6 +6 TMS arrangement (domain order: M-C-M-C).  Confers resistance to chloroquine (CQ) and primaquine (PQ), but mutations decrease resistance (Kittichai et al. 2018).

Accession Number:Q672L3
Protein Name:Mdr1
Length:1464
Molecular Weight:165406.00
Species:Plasmodium vivax [5855]
Number of TMSs:15
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKDQRQPRD NSNSSNNLSI KDEVEKELNK KGTFELYKKI KTQKIPFFLP FKCLPSSHRK 
61:	LLGVSFVCAT ISGGTLPFFV SVFGVIMKNM NLGENVNDII FSLVLIGIFQ FILSFISSFC 
121:	MDVVTTKILK TLKIEFLKSV FYQDGQFHDN NPGSKLTSDL DFYLEQVNAG IGTKFITIFT 
181:	YASAFLGLYI WSLFKNARLT LCITCVFPLI YICGVICNKK VKINKKTSLL YNNNTMSIIE 
241:	EALVGIRTVV SYCGENTILK KFNLSEKLYS KYTLKANLME SLHIGMINGF ILASYAFGFW 
301:	YGTRIIISDL SNQQPNNDFH GGSVISILLG VLISMFMLTI ILPNITEYMK SLEATNNLYE 
361:	IINRKPLVEN NQDGKKLKDI KKIQFKNVRF HYDTRKDVEI YKDLNFTLTE GKTYAFVGES 
421:	GCGKSTILKL IERLYDPTEG DVIINDSHNL KDVNLKWWRS KIGVVSQDPL LFSNSIKNNI 
481:	KYSLYSLKDL EALSEESNED GFSSQSDSNS RNSCRAKCAG DLNDMIQTTD STELIQVRKN 
541:	YETIEDSEVV SVSKKVLIHD FVSALPDKYE TLVGSNASKL SGGQKQRISI ARAIIRNPKI 
601:	LILDEATSSL DNKSEYLVQK TINNLKGNEN RITIIIAHRL STIRYANTIF VLSNRENGST 
661:	VDVDVLGEDP TKDSNEKNEK HDKQEKGGKN SSANQKIGNA GSYIIEQGTH DALMKNKNGI 
721:	YYTMINNQKV SSKSSSNNDN DKDSDMKSSI YKDSERGYDP DEANGNAKNE SASAKKSEKM 
781:	SDAKASNTNA GGRLAFLRNL FKRKPKAPNN LRVVYREIFS YKKDIAIIAL SIMVAGGLYP 
841:	LFALLYAKYV GTLFDFANLE ANSNKYSLYI LVIAIAMFIS ETLKNYYNNV IGEKVEKTMK 
901:	LRLFENILYQ EISFFDQDSH APGLLSAHIN RDVHLLKTGL VNNIVIFTHF IVLFLVSMVM 
961:	SFYFCPIVAA VLTGTYFIFM RVFAIRARIA ANKDVEKKRV NQPGTAFVYN SDDEIFKDPS 
1021:	FLIQEAFYNM NTVIIYGLED YFCTLIEKAI DYSNKGQKRK TLINSMLWGF SQSAQFFINS 
1081:	FAYWFGSFLI RRGTIQVDDF MKSLFTFLFT GSYAGKLMSL KGDSENAKLS FERYYPLITR 
1141:	KSLIDVRDNG GIKIKNSNDI KGKIEIMDVN FRYLSRPNVP IYKDLTFSCE SKKTTAIVGE 
1201:	TGSGKSTVMS LLMRFYDLKN DHHIVFKNEQ TGESSKEQMQ QGDEEQNVGM KNANEFSSSK 
1261:	EGADGQSSTL FKNSGKILLD GVDICDYNLK DLRNLFSIVS QEPMLFNMSI YENIKFGKEN 
1321:	ATREDVKRAC KFAAIDEFIE SLPNQYDTNV GPYGKSLSGG QKQRIAIARA LLREPKILLL 
1381:	DEATSSLDSN SEKLIEKTIV DIKDKADKTI ITIAHRIASI KRSDKIVVFN NPDRTGSFVQ 
1441:	AQGTHEELLS VQDGVYKKYV KLAK