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3.A.1.201.4
The multidrug resistance/chloroquine resistance protein, PfMdr1.  PfMdr1 is the central system in P. falciparum artemisinin therapy regimen resistance (Gil and Krishna 2017).  PfMDR1 is inhibited by 4 nM actelion (ACT)-213615 and actelion (ACT)-451840 (Brunner et al. 2012, Brunner et al. 2013, Krause et al. 2016),

Accession Number:P13568
Protein Name:PfMDR1
Length:1419
Molecular Weight:162252.00
Species:Plasmodium falciparum (isolate FC27 / Papua New Guinea) [5837]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate artemisinin, multiple drugs

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0055085 P:transmembrane transport

References (3)

[1] “Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum.”  Foote S.J.et.al.   2701941
[2] “Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events.”  Triglia T.et.al.   1922044
[3] “Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.”  Wilson C.M.et.al.   8426608

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP AQHRKLLFIS 
61:	FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS IGLVQFILSM ISSYCMDVIT 
121:	SKILKTLKLE YLRSVFYQDG QFHDNNPGSK LRSDLDFYLE QVSSGIGTKF ITIFTYASSF 
181:	LGLYIWSLIK NARLTLCITC VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG 
241:	IRTVASYCGE KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI 
301:	IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT NSLYEIINRK 
361:	PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS FTLKEGKTYA FVGESGCGKS 
421:	TILKLIERLY DPTEGDIIVN DSHNLKDINL KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY 
481:	SLKDLEAMEN YYEENTNDTY ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL 
541:	IHDFVSSLPD KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL 
601:	VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND DNNNNNNNNN 
661:	NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK SSNNGNDNGS DNKSSAYKDS 
721:	DTGNDADNMN SLSIHENENI SNNRNCKNTA ENEKEEKVPF FKRMFRRKKK APNNLRIIYK 
781:	EIFSYKKDVT IIFFSILVAG GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA 
841:	MFISETLKNY YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL 
901:	KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR ARLTKSKEIE 
961:	KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG LEDYFCNLIE KAIDYKNKGQ 
1021:	KRRIIVNAAL WGFSQSAQLF INSFAYWFGS FLIKRGTILV DDFMKSLFTF IFTGSYAGKL 
1081:	MSLKGDSENA KLSFEKYYPL MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN 
1141:	VPIYKNLSFT CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN 
1201:	NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL FSIVSQEPML 
1261:	FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK YDTNVGPYGK SLSGGQKQRI 
1321:	AIARALLREP KILLLDEATS SLDSNSEKLI EKTIVDIKDK ADKTIITIAH RIASIKRSDK 
1381:	IVVFNNPDRN GTFVQSHGTH DELLSAQDGI YKKYVKLAK