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3.A.1.201.5
Auxin efflux pump Pgp1 (MDR1; ABCB1) (Carraro et al. 2012). Regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase; 8.A.11.1.1 (Bouchard et al., 2006).  Involved in light-dependent hypocotyl elongation (Sidler et al. 1998). The combination of ibrutinib and paclitaxel can effectively antagonize ABCB1- or ABCC10-mediated paclitaxel resistance (Zhang et al. 2017). Pgp1 also confers herbicide tolerance to cycloheximide, toxic leves of the plant hormone N6-[2-isopentyl]adenine (2iP) and multiple herbicides (Windsor et al. 2003). It is up-regulated under salt stress conditions (Yang et al. 2018).

Accession Number:Q9ZR72
Protein Name:Pgp1 aka AtPgp1
Length:1286
Molecular Weight:140573.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Auxin

Cross database links:

Genevestigator: Q9ZR72
HEGENOM: HBG758042
RefSeq: NP_181228.1   
Entrez Gene ID: 818265   
Pfam: PF00664    PF00005   
KEGG: ath:AT2G36910   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0010329 F:auxin efflux transmembrane transporter acti...
GO:0005515 F:protein binding
GO:0043481 P:anthocyanin accumulation in tissues in resp...
GO:0009734 P:auxin mediated signaling pathway
GO:0009926 P:auxin polar transport
GO:0009640 P:photomorphogenesis
GO:0009958 P:positive gravitropism
GO:0008361 P:regulation of cell size
GO:0009637 P:response to blue light
GO:0009624 P:response to nematode
GO:0048443 P:stamen development
GO:0055085 P:transmembrane transport

References (14)

[1] “Structure of an mdr-like gene from Arabidopsis thaliana: evolutionary implications.”  Dudler R.et.al.   1372894
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development.”  Noh B.et.al.   11701880
[5] “Involvement of an ABC transporter in a developmental pathway regulating hypocotyl cell elongation in the light.”  Sidler M.et.al.   9761790
[6] “A role for ectophosphatase in xenobiotic resistance.”  Thomas C.et.al.   10760241
[7] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[8] “TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19.”  Geisler M.et.al.   14517332
[9] “Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana.”  Windsor B.et.al.   12640467
[10] “Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database.”  Nuehse T.S.et.al.   15308754
[11] “Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport.”  Lin R.et.al.   15908594
[12] “Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.”  Geisler M.et.al.   16212599
[13] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247
[14] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDNDGGAPPP PPTLVVEEPK KAEIRGVAFK ELFRFADGLD YVLMGIGSVG AFVHGCSLPL 
61:	FLRFFADLVN SFGSNSNNVE KMMEEVLKYA LYFLVVGAAI WASSWAEISC WMWSGERQTT 
121:	KMRIKYLEAA LNQDIQFFDT EVRTSDVVFA INTDAVMVQD AISEKLGNFI HYMATFVSGF 
181:	IVGFTAVWQL ALVTLAVVPL IAVIGGIHTT TLSKLSNKSQ ESLSQAGNIV EQTVVQIRVV 
241:	MAFVGESRAS QAYSSALKIA QKLGYKTGLA KGMGLGATYF VVFCCYALLL WYGGYLVRHH 
301:	LTNGGLAIAT MFAVMIGGLA LGQSAPSMAA FAKAKVAAAK IFRIIDHKPT IERNSESGVE 
361:	LDSVTGLVEL KNVDFSYPSR PDVKILNNFC LSVPAGKTIA LVGSSGSGKS TVVSLIERFY 
421:	DPNSGQVLLD GQDLKTLKLR WLRQQIGLVS QEPALFATSI KENILLGRPD ADQVEIEEAA 
481:	RVANAHSFII KLPDGFDTQV GERGLQLSGG QKQRIAIARA MLKNPAILLL DEATSALDSE 
541:	SEKLVQEALD RFMIGRTTLI IAHRLSTIRK ADLVAVLQQG SVSEIGTHDE LFSKGENGVY 
601:	AKLIKMQEAA HETAMSNARK SSARPSSARN SVSSPIMTRN SSYGRSPYSR RLSDFSTSDF 
661:	SLSIDASSYP NYRNEKLAFK DQANSFWRLA KMNSPEWKYA LLGSVGSVIC GSLSAFFAYV 
721:	LSAVLSVYYN PDHEYMIKQI DKYCYLLIGL SSAALVFNTL QHSFWDIVGE NLTKRVREKM 
781:	LSAVLKNEMA WFDQEENESA RIAARLALDA NNVRSAIGDR ISVIVQNTAL MLVACTAGFV 
841:	LQWRLALVLV AVFPVVVAAT VLQKMFMTGF SGDLEAAHAK GTQLAGEAIA NVRTVAAFNS 
901:	EAKIVRLYTA NLEPPLKRCF WKGQIAGSGY GVAQFCLYAS YALGLWYASW LVKHGISDFS 
961:	KTIRVFMVLM VSANGAAETL TLAPDFIKGG QAMRSVFELL DRKTEIEPDD PDTTPVPDRL 
1021:	RGEVELKHID FSYPSRPDIQ IFRDLSLRAR AGKTLALVGP SGCGKSSVIS LIQRFYEPSS 
1081:	GRVMIDGKDI RKYNLKAIRK HIAIVPQEPC LFGTTIYENI AYGHECATEA EIIQAATLAS 
1141:	AHKFISALPE GYKTYVGERG VQLSGGQKQR IAIARALVRK AEIMLLDEAT SALDAESERS 
1201:	VQEALDQACS GRTSIVVAHR LSTIRNAHVI AVIDDGKVAE QGSHSHLLKN HPDGIYARMI 
1261:	QLQRFTHTQV IGMTSGSSSR VKEDDA