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3.A.1.201.6
Auxin efflux pump Pgp19 (MDR11; ABCB19; ABCB21) (regulated by Twd1, an FK506-binding protein immunophilin prolyl/peptidyl isomerase (TC# 8.A.11.1.1) (Bouchard et al., 2006).

Accession Number:Q9LJX0
Protein Name:Multidrug resistance protein 11 aka Pgp19
Length:1252
Molecular Weight:136788.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Auxin

Cross database links:

Genevestigator: Q9LJX0
HEGENOM: HBG758042
RefSeq: NP_189528.1   
Entrez Gene ID: 822519   
Pfam: PF00664    PF00005   
KEGG: ath:AT3G28860   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0010329 F:auxin efflux transmembrane transporter acti...
GO:0005515 F:protein binding
GO:0010541 P:acropetal auxin transport
GO:0043481 P:anthocyanin accumulation in tissues in resp...
GO:0009734 P:auxin mediated signaling pathway
GO:0010540 P:basipetal auxin transport
GO:0048527 P:lateral root development
GO:0009640 P:photomorphogenesis
GO:0009958 P:positive gravitropism
GO:0008361 P:regulation of cell size
GO:0009637 P:response to blue light
GO:0010218 P:response to far red light
GO:0048443 P:stamen development
GO:0055085 P:transmembrane transport

References (9)

[1] “Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development.”  Noh B.et.al.   11701880
[2] “Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones.”  Kaneko T.et.al.   10907853
[3] “Functional annotation of a full-length Arabidopsis cDNA collection.”  Seki M.et.al.   11910074
[4] “PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots.”  Terasaka K.et.al.   16243904
[5] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[6] “TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19.”  Geisler M.et.al.   14517332
[7] “Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport.”  Lin R.et.al.   15908594
[8] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247
[9] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSETNTTDAK TVPAEAEKKK EQSLPFFKLF SFADKFDYLL MFVGSLGAIV HGSSMPVFFL 
61:	LFGQMVNGFG KNQMDLHQMV HEVSRYSLYF VYLGLVVCFS SYAEIACWMY SGERQVAALR 
121:	KKYLEAVLKQ DVGFFDTDAR TGDIVFSVST DTLLVQDAIS EKVGNFIHYL STFLAGLVVG 
181:	FVSAWKLALL SVAVIPGIAF AGGLYAYTLT GITSKSRESY ANAGVIAEQA IAQVRTVYSY 
241:	VGESKALNAY SDAIQYTLKL GYKAGMAKGL GLGCTYGIAC MSWALVFWYA GVFIRNGQTD 
301:	GGKAFTAIFS AIVGGMSLGQ SFSNLGAFSK GKAAGYKLME IINQRPTIIQ DPLDGKCLDQ 
361:	VHGNIEFKDV TFSYPSRPDV MIFRNFNIFF PSGKTVAVVG GSGSGKSTVV SLIERFYDPN 
421:	SGQILLDGVE IKTLQLKFLR EQIGLVNQEP ALFATTILEN ILYGKPDATM VEVEAAASAA 
481:	NAHSFITLLP KGYDTQVGER GVQLSGGQKQ RIAIARAMLK DPKILLLDEA TSALDASSES 
541:	IVQEALDRVM VGRTTVVVAH RLCTIRNVDS IAVIQQGQVV ETGTHEELIA KSGAYASLIR 
601:	FQEMVGTRDF SNPSTRRTRS TRLSHSLSTK SLSLRSGSLR NLSYSYSTGA DGRIEMISNA 
661:	ETDRKTRAPE NYFYRLLKLN SPEWPYSIMG AVGSILSGFI GPTFAIVMSN MIEVFYYTDY 
721:	DSMERKTKEY VFIYIGAGLY AVGAYLIQHY FFSIMGENLT TRVRRMMLSA ILRNEVGWFD 
781:	EDEHNSSLIA ARLATDAADV KSAIAERISV ILQNMTSLLT SFIVAFIVEW RVSLLILGTF 
841:	PLLVLANFAQ QLSLKGFAGD TAKAHAKTSM IAGEGVSNIR TVAAFNAQSK ILSLFCHELR 
901:	VPQKRSLYRS QTSGFLFGLS QLALYGSEAL ILWYGAHLVS KGVSTFSKVI KVFVVLVITA 
961:	NSVAETVSLA PEIIRGGEAV GSVFSVLDRQ TRIDPDDADA DPVETIRGDI EFRHVDFAYP 
1021:	SRPDVMVFRD FNLRIRAGHS QALVGASGSG KSSVIAMIER FYDPLAGKVM IDGKDIRRLN 
1081:	LKSLRLKIGL VQQEPALFAA TIFDNIAYGK DGATESEVID AARAANAHGF ISGLPEGYKT 
1141:	PVGERGVQLS GGQKQRIAIA RAVLKNPTVL LLDEATSALD AESECVLQEA LERLMRGRTT 
1201:	VVVAHRLSTI RGVDCIGVIQ DGRIVEQGSH SELVSRPEGA YSRLLQLQTH RI