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3.A.1.201.8
The aluminum chelate (aluminum sensitivity (ALS1)) protein; expressed in root vacuoles half-type ABC transporter (not induced by aluminum; Larsen et al., 2007).

Accession Number:Q0WML0
Protein Name:ALS1
Length:644
Molecular Weight:69104.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Al3+

Cross database links:

Genevestigator: Q0WML0
eggNOG: KOG0058
HEGENOM: HBG758042
RefSeq: NP_198720.2   
Entrez Gene ID: 833896   
Pfam: PF00664    PF00005   
KEGG: ath:AT5G39040   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000325 C:plant-type vacuole
GO:0005886 C:plasma membrane
GO:0005774 C:vacuolar membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0010044 P:response to aluminum ion
GO:0055085 P:transmembrane transport

References (5)

[1] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[2] “Arabidopsis ALS1 encodes a root tip and stele localized half type ABC transporter required for root growth in an aluminum toxic environment.”  Larsen P.B.et.al.   17171374
[3] “Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones.”  Asamizu E.et.al.   10048488
[4] “Mapping the Arabidopsis organelle proteome.”  Dunkley T.P.J.et.al.   16618929
[5] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNKKLLTGG SSKTHGSGSS YRDPLLQNQE DKPKANGSEN GLNDLEHGVV EAANVGFGRV 
61:	FALAKPDAGK LVIGTIALLI GSTTNLLVPK FGGMIIDIVS RDVKTPEQQT ESLIAVRNAV 
121:	VIILLIVVIG SICTALRAWL FNSASERVVA RLRKDLFRHL MHQEIAFYDV TKTGELLSRL 
181:	SEDTQIIKNA ATTNLSEALR NVTTALIGVG FMFTSSWKLT LLALVVVPVI SVAVKQFGRY 
241:	LRELSHTTQA AAAVAASIAE ESFGAVRTVR SFAKESYMVS QYSKKVDETL KLGLKQAVLV 
301:	GLFFGGLNAA FTLSVITVVS YGAYLTIYGS MTVGALTSFI LYSLTVGSSV SSLSSLYTTA 
361:	MKAAGASRRV FQILDRVSSM SSSGDKCPVG NPDGDVELND VWFAYPSRPS HMILKGISLR 
421:	LTPGSKVALV GPSGGGKTTI ANLIERFYDP LKGKILLNGV SLMEISHQYL HKQISIVSQE 
481:	PILFNCSVEE NIAYGFDGEA SFTDIENAAK MANAHEFIEA FPDKYNTVVG ERGLRLSGGQ 
541:	KQRIAIARAL LTNPSVLLLD EATSALDAES EYLVQDAMDS LMAGRTVLVI AHRLSTVKTA 
601:	DCVAVISDGE VAEKGTHDEL LSLNGIYTNL VKRQLQSSSS VTTL