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3.A.1.201.9
Marine skate liver bile salt exporter, BSEP (1348 aas) (transports taurocholine in an ATP-dependent fashion (Cai et al., 2001)) (Most similar to 3.A.1.201.2)

Accession Number:Q90Z35
Protein Name:BSEP
Length:1348
Molecular Weight:148649.00
Species:Raja erinacea (Little skate) [7782]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate bile salts, Taurocholine

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (1)

[1] “Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations.”  Cai S.Y.et.al.   11447010

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MPNSVVLRRF NSLGEDNKAF QAEYLDIDGP GQRKVYTVNG NYPSKSKDDN ENLSKKGDRI 
61:	KIGFFQLFRF ASCYEVTLMV FGGVCALLHG VAQPAVLLVF GLLTDTFIAY DIELQELKDT 
121:	RKHCDNNTIH WVNGSEYLNQ HNETMSCGIL NIEKEMTMFA YYYVGIGCSV LLLGYFQICF 
181:	WVTAAARQTQ KIRKAYFRQI MRMEMGWFDC NSVGELNTRM SDDINKINDA IADQVGIFIQ 
241:	RFSTFVSGFL MGFVNGWKLT LVIIAVSPLI GLGAALMALS VARLTGLGLK AYAKAGAVAD 
301:	EVLSSIRTVA AFSGEKKEVD RYDRNLVFAQ RWGIRKGMIM GFFTGYVWMI IFCCYALAFW 
361:	YGSKLVIEQN EYTPGGLLQV FLGVLVAAMN LGQASPCLEA FASGRGAAVK IFETIDREPE 
421:	IDCMSEGGYT LNKVKGDIEF HNVTFNYPSR PDVKTLDRLS MVIKAGETTA FVGPSGSGKS 
481:	TAVELIQRFY DPKQGMVTLD GHDIRSLNIQ WLRSLIGIVE QEPVLFSTTI EENIRYVREG 
541:	LTKNDIVQAA KEANAYDFIM DLPEKFNTLV GEGGGQMSGG QKQRIAIARA LVRNPKILLL 
601:	DMATSALDNE SEAIVQGALD KVRFGRTTIS IAHRLSTVRN VDVIIGFEHG RAVERGRHAE 
661:	LLERKGIYFT LVTLQTQGEQ ALHEKARQVN GAIEDGASEK RQLIRRGSSR ASVRSTRHQR 
721:	SRSQVSEVLS DLSGPGDVAS AVRTPSISLG DEDKDVEEEE ESIEPAPVSR ILKYNVSEWP 
781:	YMLFGSLGAA VNGGVNPIYA LLFSQILGTF SLQNEEEKIN QINAICLFFV VVGLVSFLTQ 
841:	FLQSYFFAKS GELLTRRLRK LGFQAMLRQE IGWFDDRKNS PGTLTTRLAT DASQVQGATG 
901:	TQIGMIVNSI TNIGVSLIIA FYFSWKLTLV ILCFLPFLAL TGALQARMLT GFANQDKEAL 
961:	EAAGQISSEA LSNIRTIAGL AKEKMFVQLF EAQLEAPYKA AIKKANVYGL CFGFAQSVIF 
1021:	LANAASYRFG GYLVVAENLH FSIVFRVISA IVTSGTALGR ASSYTPDYAK AKIAAARFFQ 
1081:	LIDRAPKINI DSSEGEKWSN FRGDIKFVEC TFTYPTRPDF QVLNGLSVCV MPGQTLAFVG 
1141:	SSGCGKSTSV QLLERFYDPN QGRVIIDGRS TTNVNTAFLR SKIGIVSQEP VLFDSSIEEN 
1201:	IKYGDNSRQV SMDEVIAAAK KAQLHSFVMS LPEKYGTRVG AQGSQLSRGQ KQRIAIARAI 
1261:	VRDPKILLLD EATSALDTES EKIVQDALDE ARKGRTCIVI AHRLSTIQNS DIIAVMSRGI 
1321:	IIEQGSHGNL MAAKGAYYKL VTTGAPIS