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3.A.1.202.2
CFTR of    Epithelial ion channel that plays a role in the regulation of epithelial ion and water transport and fluid homeostasis (Bagnat et al. 2010; Navis et al. 2013; Navis and Bagnat 2015). It mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. CFTR exerts its function in part by modulating the activity of other ion channels and transporters, and it contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Required for normal fluid homeostasis in the gut (Bagnat et al. 2010) and for normal volume expansion of Kupffer's vesicle during embryonic development as well as for normal establishment of left-right body patterning (Navis et al. 2013; Roxo-Rosa et al. 2015). It is also required for normal resistance to infection by Pseudomonas aeruginosa  (Phennicie et al. 2010).

Accession Number:Q1LX78
Protein Name:Cystic fibrosis transmembrane conductance regulator
Length:1485
Molecular Weight:168400.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQRSPVEDAN CLSRYFFWWT NPIMRKGFKE KLRPSDVYQA PSQDAADILA ERLEKEWDRE 
61:	VASGKKKPSL LRAMARCYIK PFLLFGFLLY IGEATKTVQP QLLGRIIASF DPAHEPERAN 
121:	GYFLAFGLGL LFTARFLLLQ PAMFGLHHLG MQIRIALFSI IYKKTLKLSS RVLDKISTGQ 
181:	LVSLMSANLG KFDQSLGMAH FIWISPLQCI LCTGLIWELI DVNSFCALAA ISLLGVLQAF 
241:	LSHKMGPYKA QKVLLTNKRL ALTSEIMENL HSVKAYGWEE IMETLIKNIR QDEVKLTRKI 
301:	GSLRYFYSSA YFFSAIFVIV AAVVPHALSR GINLRRIFTT LSYCMVLRMT VTRQLPGSIQ 
361:	MWYDTMRLIW KIEEFLSKEE YKLMEYDLSI TELELQDVTA SWDEGPGELL ERIKQENKAN 
421:	GHHNGDAGLF FTNLYVAPVL KDISLKLKKG EMLAVTGSMG SGKSSLLMTI LGELVPSSGK 
481:	IRHSGRISYS SQTAWIMPGT IRDNILFGLT YDEYRYKSVV KACQLEEDLA ALPEKDKTPM 
541:	AEGGLNLSGG QKARVALARA VYRDADLYLL DAPFTHLDIA TEKEIFDKCL CKLMASKTRI 
601:	LVTNKIEHLK RADKILLLHN GESFFYGTFP ELQSERPDFS SLLLGLEAYD NISAERRCSI 
661:	LTETLHRVSV DESAGMQPER SAFRQVPPTK PMYIDERKAS VIVNPLGVAR KASFIQVPEE 
721:	EVRRTLPDRK FSLVPENELV DESFMGSDVY HNHGVHMAGQ RRQSVLAFMT NAQGQGRREH 
781:	LQSSFRRRLS VVPQSELASE LDIYTRRLSD STYDMTGILE EENIEACLTD EIDEIEETFE 
841:	TTKWNTYVRY VSNNKSLLYV LIFILFIAAI EIAGSVAGIF LITDELWREE HQRSEPNMTK 
901:	HSNASSSGQT YAITVTPTSS YYILYIYVAT SESLLAMGFF RGLPFVHTTI TISKKLHQKM 
961:	LHAVLSAPMS VLNTMKTGRI MNRFTKDMAT IDDMLPLLMF DFVQLTVVVV GCILVVSIVR 
1021:	PYIFLAATPL AIIFIVMRKY FLRTGQQLKQ LETEARSPIF SHLIMSLKGL WTIRAFERQA 
1081:	YFEALFHKTL NTHTATWFLY LSTLRWFLFR ADILFVFFFT LAAWIAVGTN QDKPGEIGII 
1141:	ICLAMLILGT FQWCVATSIA VDGMMRSVDR VFKFIDLPSE TPKPDKGKDS DLIIENVDAQ 
1201:	ADSSWPHRGQ IEVRNLTVKY TEAGHAVLKN LSFSAEGRQR VGILGRTGSG KSSLFNALLK 
1261:	LVYTDGEISI DGVNWNKMPL QKWRKAFGVV PQKVFIFTGP LRMNLDPYGC HSDEELWRVA 
1321:	EEVGLKTVIE QFPDKLDFQL EYGGYVLSNG HKQLICLARS ILSGARILLL DEPSAHLDPV 
1381:	TIKVLKKTLR QSFSTCTILL SEHKVEPLLE CQSFLMMDKG QVKTYDSIQK LLNETSHLKQ 
1441:	AISPAERLKL FPRRNSSMRT PQSKLSSVTQ TLQEEAEDNI QDTRL