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3.A.1.203.4
The BacA (Rv1819c) porter (selective for the uptake of bleomycin and antimicrobial peptides) (essential for maintenance of extended chronic infection) (Domenech et al., 2009).

Accession Number:Q50614
Protein Name:Uncharacterized ABC transporter ATP-binding protein Rv1819c/MT1867
Length:639
Molecular Weight:71317.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Bleomycin, Antimicrobial peptides

Cross database links:

HEGENOM: HBG555665
RefSeq: NP_216335.1    NP_336326.1   
Entrez Gene ID: 885539    923763   
Pfam: PF06472    PF00005   
KEGG: mtc:MT1867    mtu:Rv1819c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGPKLFKPSI DWSRAFPDSV YWVGKAWTIS AICVLAILVL LRYLTPWGRQ FWRITRAYFV 
61:	GPNSVRVWLM LGVLLLSVVL AVRLNVLFSY QGNDMYTALQ KAFEGIASGD GTVKRSGVRG 
121:	FWMSIGVFSV MAVLHVTRVM ADIYLTQRFI IAWRVWLTHH LTQDWLDGRA YYRDLFIDET 
181:	IDNPDQRIQQ DVDIFTAGAG GTPNAPSNGT ASTLLFGAVQ SIISVISFTA ILWNLSGTLN 
241:	IFGVSIPRAM FWTVLVYVFV ATVISFIIGR PLIWLSFRNE KLNAAFRYAL VRLRDAAEAV 
301:	GFYRGERVEG TQLQRRFTPV IDNYRRYVRR SIAFNGWNLS VSQTIVPLPW VIQAPRLFAG 
361:	QIDFGDVGQT ATSFGNIHDS LSFFRNNYDA FASFRAAIIR LHGLVDANEK GRALPAVLTR 
421:	PSDDESVELN DIEVRTPAGD RLIDPLDVRL DRGGSLVITG RSGAGKTTLL RSLAELWPYA 
481:	SGTLHRPGGE NETMFLSQLP YVPLGTLRDV VCYPNSAAAI PDATLRDTLT KVALAPLCDR 
541:	LDEERDWAKV LSPGEQQRVA FARILLTKPK AVFLDESTSA LDTGLEFALY QLLRSELPDC 
601:	IVISVSHRPA LERLHENQLE LLGGGQWRLA PVEAAPAEV