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3.A.1.204.15
MDR efflux pump, ABCG2a.  Exports canonical MDR susbtrates such as calcein-AM, bodipy-verapamil, bodipy-vinblastine and mitoxantrone (Gokirmak et al. 2012).

Accession Number:I0DHI9
Protein Name:ATP-binding cassette transporter subfamily G member 2a
Length:703
Molecular Weight:77971.00
Species:Strongylocentrotus purpuratus (Purple sea urchin) [7668]
Number of TMSs:6
Substrate Calcein-AM, Bodipy-vinblastine, mitoxantrone

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGEEHEQDT HFGATEETPT TVAPSRDPEN DQPAVLEVNH NDTGPGDMKI NMDPVLSDPE 
61:	KHKLGYGSVT NGHSSHTKVH PSFARSTSID GSVVSFHAIT YTVKTKENRK KVTKTILTDV 
121:	NGLFKPGMNA ILGPTGSGKT SLLDVLAARK DPDGLSGQVL IDGAPQPKNF KCVSGYVVQD 
181:	DVVMGTLTIR ENLQFSAALR LPKTVGKKER EDRVDDILAE LGLSHVGDSK VGTEFIRGVS 
241:	GGERKRTNVG MELITKPSVL FLDEPTTGLD ASTANAVMHL LASLSKRGRT IIFSIHQPRY 
301:	SIFRLFDKMH LLGQGRTIYH GPAQEALEYF SSIGFECEEH NNPPDFFLDV ILGQSDLKSS 
361:	EKDQEDVESG VAAIENGEKS KVILADCYEK SHYNKTMKEA TESIYTQYRN DEEPSIVSIN 
421:	YPTSFFSQLY HVSHRAVLNI LRNPFLTVIQ NATVILFSVV IGGIYFQLDT SISSGYQNRI 
481:	GAFFFLIMQM VFGNLSAVEL FIRERVIFIH ESASGFYRVS VYFVAKVFCD LLPLRVIPTI 
541:	LYVVVTYWMI GLQADATKFF LYFLTLLLVT FVSSALAFAI SSSVSIAGIA TLLIAMCYVL 
601:	MMVFGGLLVN ISSLPVWLQW LQYLSIFRFG LNALLINEMV GLDFCETVGN VTLRCIPGTD 
661:	YLDQQGIDYS DWGLWQNEMA LGIMTVALLA IAYIQLRRIP KLK