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3.A.1.204.17
Scarlet.  Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. The scarlet and white (TC# 3.A.1.204.1) complex probably transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules (Tearle et al. 1989). These proteins are located in the membranes of pigment granules within pigment cells and retinula cells of the compound eye (Mackenzie et al. 2000). Knockouts of scarlet in the noctuid moth, Helicoverpa armigera, are viable and produce pigmentless first instar larvae and yellow adult eyes lacking xanthommatin (Khan et al. 2017).

Accession Number:P45843
Protein Name:Protein scarlet
Length:666
Molecular Weight:74458.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate 3-hydroxy kynurenine, pigment precursors

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FASTA formatted sequence
1:	MSDSDSKRID VEAPERVEQH ELQVMPVGST IEVPSLDSTP KLSKRNSSER SLPLRSYSKW 
61:	SPTEQGATLV WRDLCVYTNV GGSGQRMKRI INNSTGAIQP GTLMALMGSS GSGKTTLMST 
121:	LAFRQPAGTV VQGDILINGR RIGPFMHRIS GYVYQDDLFL GSLTVLEHLN FMAHLRLDRR 
181:	VSKEERRLII KELLERTGLL SAAQTRIGSG DDKKVLSGGE RKRLAFAVEL LNNPVILFCD 
241:	EPTTGLDSYS AQQLVATLYE LAQKGTTILC TIHQPSSQLF DNFNNVMLLA DGRVAFTGSP 
301:	QHALSFFANH GYYCPEAYNP ADFLIGVLAT DPGYEQASQR SAQHLCDQFA VSSAAKQRDM 
361:	LVNLEIHMAQ SGNFPFDTEV ESFRGVAWYK RFHVVWLRAS LTLLRDPTIQ WLRFIQKIAM 
421:	AFIIGACFAG TTEPSQLGVQ AVQGALFIMI SENTYHPMYS VLNLFPQGFP LFMRETRSGL 
481:	YSTGQYYAAN ILALLPGMII EPLIFVIICY WLTGLRSTFY AFGVTAMCVV LVMNVATACG 
541:	CFFSTAFNSV PLAMAYLVPL DYIFMITSGI FIQVNSLPVA FWWTQFLSWM LYANEAMTAA 
601:	QWSGVQNITC FQESADLPCF HTGQDVLDKY SFNESNVYRN LLAMVGLYFG FHLLGYYCLW 
661:	RRARKL