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3.A.1.204.4
The plant cuticular wax and/or lipid metabolite exporter, CER5; ABCG12; WBC12 (in the plasma membrane of epidermal cells; secretes wax to the plant surface) (Pighin et al., 2004; Panikashvili and Aharoni 2008Panikashvili and Aharoni 2008).

Accession Number:Q9C8K2
Protein Name:ATP-dependent transmembrane transporter, putative; aka At1g51500/F5D21_6 aka At1g51560 aka ABC transporter CER5
Length:687
Molecular Weight:76451.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cuticular wax

Cross database links:

Genevestigator: Q9C8K2
eggNOG: KOG0061
HEGENOM: HBG595388
RefSeq: NP_175561.1   
Entrez Gene ID: 841575   
Pfam: PF01061    PF00005   
KEGG: ath:AT1G51500   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006869 P:lipid transport
GO:0009737 P:response to abscisic acid stimulus
GO:0009651 P:response to salt stress
GO:0010025 P:wax biosynthetic process

References (8)

[1] “Plant cuticular lipid export requires an ABC transporter.”  Pighin J.A.et.al.   15499022
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[5] “Cuticular waxes on eceriferum mutants of Arabidopsis thaliana.”  Rashotte A.M.et.al.   11336252
[6] “The Arabidopsis DESPERADO/AtWBC11 transporter is required for cutin and wax secretion.”  Panikashvili D.et.al.   17951461
[7] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247
[8] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELESTSNGR RPPPPAEIGR GAYLAWEDLT VVIPNFSGGP TRRLLDGLNG HAEPGRIMAI 
61:	MGPSGSGKST LLDSLAGRLA RNVIMTGNLL LNGKKARLDY GLVAYVTQED ILMGTLTVRE 
121:	TITYSAHLRL SSDLTKEEVN DIVEGTIIEL GLQDCADRVI GNWHSRGVSG GERKRVSVAL 
181:	EILTRPQILF LDEPTSGLDS ASAFFVIQAL RNIARDGGRT VVSSIHQPSS EVFALFDDLF 
241:	LLSSGETVYF GESKFAVEFF AEAGFPCPKK RNPSDHFLRC INSDFDTVTA TLKGSQRIRE 
301:	TPATSDPLMN LATSEIKARL VENYRRSVYA KSAKSRIREL ASIEGHHGME VRKGSEATWF 
361:	KQLRTLTKRS FVNMCRDIGY YWSRIVIYIV VSFCVGTIFY DVGHSYTSIL ARVSCGGFIT 
421:	GFMTFMSIGG FPSFIEEMKV FYKERLSGYY GVSVYIISNY VSSFPFLVAI ALITGSITYN 
481:	MVKFRPGVSH WAFFCLNIFF SVSVIESLMM VVASLVPNFL MGLITGAGII GIIMMTSGFF 
541:	RLLPDLPKVF WRYPISFMSY GSWAIQGAYK NDFLGLEFDP MFAGEPKMTG EQVINKIFGV 
601:	QVTHSKWWDL SAIVLILVCY RILFFIVLKL KERAEPALKA IQAKRTMKSL KKRPSFKKVP 
661:	SLSSLSSRRH QPLHSLSSQE GLTSPIN