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3.A.1.204.6
The efflux porter for phosphatidylcholine and its analogues as well as toxic alkyl phospholipids, ABCG4 (Castanys-Munoz et al., 2007). Also promotes cholesterol efflux to the mature forms of HDL (HDL2 and HDL3) (Voloshyna and Reiss, 2011).

Accession Number:A4HWI7
Protein Name:ABCG4
Length:741
Molecular Weight:83045.00
Species:Leishmania infantum [5671]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Phosphatidylcholine, alkyl phospholipids, cholesterol

Cross database links:

eggNOG: KOG0061
HEGENOM: HBG521184
RefSeq: XP_001464428.1   
Entrez Gene ID: 5067821   
Pfam: PF01061    PF00005   

Gene Ontology

GO:0016020 C:membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity

References (1)

[1] “Comparative genomic analysis of three Leishmania species that cause diverse human disease.”  Peacock C.S.et.al.   17572675

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGTQVDQAHK PSVGTPTELT SIPPTASVTP PQAKSNAEDA KVPALSRAVN FTWENLTYQV 
61:	PVEDKDGNVI YKTLLFNLSG CAKGGRVLAI MGPSGAGKTT LMGTITGKLF NATARQEGCC 
121:	FMNNNIYQQR YKRLVSYVCQ DDIVMGKDTP REAIYFSARL RLGLDSETAR RRVADVIKRL 
181:	SLTKCQDTIL GIPGILKGVS GGERKRANIG TELVTNPFVM LLDEPTTGLD SVNAVRVGHL 
241:	LQDLAKNDMR TVIATVHSPS SELFDLFDDL LLLAKGHVIY HGPTADSIEY FASLGYDVPP 
301:	RTNPTEYFMN LLQLPEEILS QLWLAWEDYV MSDAANDNPC LTPVTGVITL TDDYLEEQLE 
361:	LKGANFCLQF SELFKRSWRM YLRDPGNFYG RSVQTLFFAI FVGLFFFNLQ LNQQGVQDRL 
421:	GALYVTLMNN LFGAAMNGIA AFPPERAVFL QEQANDAYNA YTYFLAKNLA ELPWQILFPT 
481:	VFDLIAYFMI HFHRSAGAFF VHWFILVLLA NLGYSFGLMF ATFFKQSQAA FAMVPLILLP 
541:	LFIVAGLFAN TDRLYPYWEW LNYISFPRHA YLGVFTNEFE RLTVICDPVT PLCTFPDGQA 
601:	VIEYMGFQGW HYWQTFVALI VYQIGLRFIG ATSLYYQGRQ RRGKLQFVKN LRKRVASPRA 
661:	IASARSNDEL SDVQSTLVGS IATPSNAYGT GVSSPINNPE NHQPIWDGES ERATLALPDT 
721:	PVTYVESPVD VKDMKPRKYR S