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3.A.1.204.8
The epidermal plasma membrane cuticular lipid (wax) exporters, ABCG11/ABCG11 and ABCG11/ABCG12; ABCG11 is also called Wbc11; Desperado (DSO); COF1; PEL1. ABCG12 is also called CER5, WBC12 and D3 (Panikashvili and Aharoni 2008).  Required for the cuticle and pollen coat development by controlling cutin and possibly wax transport to the extracellular matrix. Involved in developmental plasticity and stress responses (Bird et al. 2007).  ABCG11 can traffic to the plasma membrane in the absence of ABCG12 and can form flexible dimers. By contrast, ABCG12 was retained in the endoplasmic reticulum in the absence of ABCG11, indicating that ABCG12 can only form dimers with ABCG11 in the plasm membrane of epidermal cells. Some ABCG proteins may be promiscuous, having multiple partnerships, while others may form obligate heterodimers for specialized functions (McFarlane et al. 2010).

Accession Number:Q8RXN0
Protein Name:ABC transporter G family member 11
Length:703
Molecular Weight:78413.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate waxes, cuticular lipids

Cross database links:

Genevestigator: Q8RXN0
eggNOG: KOG0061
HEGENOM: HBG595388

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEIEASRQQT TVPVSVGGGN FPVGGLSPLS EAIWREKAPT EFVGDVSARL TWQDLTVMVT 
61:	MGDGETQNVL EGLTGYAEPG SLTALMGPSG SGKSTMLDAL ASRLAANAFL SGTVLLNGRK 
121:	TKLSFGTAAY VTQDDNLIGT LTVRETIWYS ARVRLPDKML RSEKRALVER TIIEMGLQDC 
181:	ADTVIGNWHL RGISGGEKRR VSIALEILMR PRLLFLDEPT SGLDSASAFF VTQTLRALSR 
241:	DGRTVIASIH QPSSEVFELF DRLYLLSGGK TVYFGQASDA YEFFAQAGFP CPALRNPSDH 
301:	FLRCINSDFD KVRATLKGSM KLRFEASDDP LEKITTAEAI RLLVDYYHTS DYYYTAKAKV 
361:	EEISQFKGTI LDSGGSQASF LLQTYTLTKR SFINMSRDFG YYWLRLLIYI LVTVCIGTIY 
421:	LNVGTSYSAI LARGSCASFV FGFVTFMSIG GFPSFVEDMK VFQRERLNGH YGVAAFVIAN 
481:	TLSATPFLIM ITFISGTICY FMVGLHPGFT HYLFFVLCLY ASVTVVESLM MAIASIVPNF 
541:	LMGIIIGAGI QGIFMLVSGF FRLPNDIPKP FWRYPMSYIS FHFWALQGQY QNDLRGLTFD 
601:	SQGSAFKIPG EYVLENVFQI DLHRSKWINL SVILSMIIIY RIIFFIMIKT NEDVTPWVRG 
661:	YIARRRMKQK NGTQNTTVAP DGLTQSPSLR NYIATRTDGA RRW