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3.A.1.205.10
Pleiotropic drug resistance (PDR) exporter, named ABCG40, PDR9 or PDR12, 1423 aas with 12 - 14 TMSs. It functions as a pump to exclude Pb2+ ions and/or Pb2+- containing toxin compounds) (Lee et al., 2005). It may also export abscisic acid (ABA) (Lefèvre and Boutry 2018).

Accession Number:Q9M9E1
Protein Name:Pleiotropic drug resistance protein 12 aka PDR12
Length:1423
Molecular Weight:161017.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Pb2+, drugs

Cross database links:

Genevestigator: Q9M9E1
eggNOG: KOG0065
HEGENOM: HBG750535
RefSeq: NP_173005.1   
Entrez Gene ID: 838122   
Pfam: PF01061    PF00005    PF08370   
KEGG: ath:AT1G15520   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006952 P:defense response
GO:0015692 P:lead ion transport
GO:0009607 P:response to biotic stimulus
GO:0009723 P:response to ethylene stimulus
GO:0009753 P:response to jasmonic acid stimulus
GO:0010193 P:response to ozone
GO:0009751 P:response to salicylic acid stimulus
GO:0046865 P:terpenoid transport

References (7)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “The plant PDR family of ABC transporters.”  van den Brule S.et.al.   12430018
[3] “Pathogen-responsive expression of a putative ATP-binding cassette transporter gene conferring resistance to the diterpenoid sclareol is regulated by multiple defense signaling pathways in Arabidopsis.”  Campbell E.J.et.al.   14526118
[4] “AtPDR12 contributes to lead resistance in Arabidopsis.”  Lee M.et.al.   15923333
[5] “Organization and function of the plant pleiotropic drug resistance ABC transporter family.”  Crouzet J.et.al.   16506311
[6] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247
[7] “Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana.”  Jones A.M.E.et.al.   19245862

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGTSFHQAS NSMRRNSSVW KKDSGREIFS RSSREEDDEE ALRWAALEKL PTFDRLRKGI 
61:	LTASHAGGPI NEIDIQKLGF QDTKKLLERL IKVGDDEHEK LLWKLKKRID RVGIDLPTIE 
121:	VRFDHLKVEA EVHVGGRALP TFVNFISNFA DKFLNTLHLV PNRKKKFTIL NDVSGIVKPG 
181:	RMALLLGPPS SGKTTLLLAL AGKLDQELKQ TGRVTYNGHG MNEFVPQRTA AYIGQNDVHI 
241:	GEMTVRETFA YAARFQGVGS RYDMLTELAR REKEANIKPD PDIDIFMKAM STAGEKTNVM 
301:	TDYILKILGL EVCADTMVGD DMLRGISGGQ KKRVTTGEML VGPSRALFMD EISTGLDSST 
361:	TYQIVNSLRN YVHIFNGTAL ISLLQPAPET FNLFDDIILI AEGEIIYEGP RDHVVEFFET 
421:	MGFKCPPRKG VADFLQEVTS KKDQMQYWAR RDEPYRFIRV REFAEAFQSF HVGRRIGDEL 
481:	ALPFDKTKSH PAALTTKKYG VGIKELVKTS FSREYLLMKR NSFVYYFKFG QLLVMAFLTM 
541:	TLFFRTEMQK KTEVDGSLYT GALFFILMML MFNGMSELSM TIAKLPVFYK QRDLLFYPAW 
601:	VYSLPPWLLK IPISFMEAAL TTFITYYVIG FDPNVGRLFK QYILLVLMNQ MASALFKMVA 
661:	ALGRNMIVAN TFGAFAMLVF FALGGVVLSR DDIKKWWIWG YWISPIMYGQ NAILANEFFG 
721:	HSWSRAVENS SETLGVTFLK SRGFLPHAYW YWIGTGALLG FVVLFNFGFT LALTFLNSLG 
781:	KPQAVIAEEP ASDETELQSA RSEGVVEAGA NKKRGMVLPF EPHSITFDNV VYSVDMPQEM 
841:	IEQGTQEDRL VLLKGVNGAF RPGVLTALMG VSGAGKTTLM DVLAGRKTGG YIDGNITISG 
901:	YPKNQQTFAR ISGYCEQTDI HSPHVTVYES LVYSAWLRLP KEVDKNKRKI FIEEVMELVE 
961:	LTPLRQALVG LPGESGLSTE QRKRLTIAVE LVANPSIIFM DEPTSGLDAR AAAIVMRTVR 
1021:	NTVDTGRTVV CTIHQPSIDI FEAFDELFLL KRGGEEIYVG PLGHESTHLI NYFESIQGIN 
1081:	KITEGYNPAT WMLEVSTTSQ EAALGVDFAQ VYKNSELYKR NKELIKELSQ PAPGSKDLYF 
1141:	PTQYSQSFLT QCMASLWKQH WSYWRNPPYT AVRFLFTIGI ALMFGTMFWD LGGKTKTRQD 
1201:	LSNAMGSMYT AVLFLGLQNA ASVQPVVNVE RTVFYREQAA GMYSAMPYAF AQVFIEIPYV 
1261:	LVQAIVYGLI VYAMIGFEWT AVKFFWYLFF MYGSFLTFTF YGMMAVAMTP NHHIASVVSS 
1321:	AFYGIWNLFS GFLIPRPSMP VWWEWYYWLC PVAWTLYGLI ASQFGDITEP MADSNMSVKQ 
1381:	FIREFYGYRE GFLGVVAAMN VIFPLLFAVI FAIGIKSFNF QKR