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3.A.1.205.11
The brefeldin resistance protein, Bfr1, (also exports actinomycin D, cerulenin, and cytochalasin B) (Turi and Rose, 1995; Nagao et al., 1995).

Accession Number:P41820
Protein Name:Brefeldin A resistance protein aka Bfr1
Length:1530
Molecular Weight:171751.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Brefeldin, Actinomycin D, Cerulenin, Cytochalasin B

Cross database links:

eggNOG: fuNOG04532
HEGENOM: HBG323792
RefSeq: NP_587932.3   
Entrez Gene ID: 2539195   
Pfam: PF01061    PF00005    PF06422   
KEGG: spo:SPCC18B5.01   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0033554 P:cellular response to stress
GO:0046677 P:response to antibiotic

References (4)

[1] “bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily.”  Nagao K.et.al.   7883711
[2] “Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin A resistance.”  Turi T.G.et.al.   7646493
[3] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNQNSDTTHG QALGSTLNHT TEVTRISNSS DHFEDSSSNV DESLDSSNPS SNEKASHTNE 
61:	EYRSKGNQSY VPSSSNEPSP ESSSNSDSSS SDDSSVDRLA GDPFELGENF NLKHYLRAYK 
121:	DSLQRDDIIT RSSGVCMRDH SVYGVGSGYE FLKTFPDIFL QPYRAITEKQ VVEKAILSHC 
181:	HALANAGELV MVLGQPGSGC STFLRSVTSD TVHYKRVEGT THYDGIDKAD MKKFFPGDLL 
241:	YSGENDVHFP SLTTAETLDF AAKCRTPNNR PCNLTRQEYV SRERHLIATA FGLTHTFNTK 
301:	VGNDFVRGVS GGERKRVTIS EGFATRPTIA CWDNSTRGLD SSTAFEFVNV LRTCANELKM 
361:	TSFVTAYQAS EKIYKLFDRI CVLYAGRQIY YGPADKAKQY FLDMGFDCHP RETTPDFLTA 
421:	ISDPKARFPR KGFENRVPRT PDEFEQMWRN SSVYADLMAE MESYDKRWTE TTPASSEAPE 
481:	KDNFGSDISA TTKHELYRQS AVAEKSKRVK DTSPYTVTFS QQLWYCLARS WERYINDPAY 
541:	IGSMAFAFLF QSLIIGSIFY DMKLNTVDVF SRGGVLFFSI LFCALQSLSE IANMFSQRPI 
601:	IAKHRASALY HPAADVISSL IVDLPFRFIN ISVFSIVLYF LTNLKRTAGG FWTYFLFLFI 
661:	GATCMSAFFR SLAGIMPNVE SASALGGIGV LAIAIYTGYA IPNIDVGWWF RWIAYLDPLQ 
721:	FGFESLMINE FKARQFECSQ LIPYGSGYDN YPVANKICPV TSAEPGTDYV DGSTYLYISF 
781:	NYKTRQLWRN LAIIIGYYAF LVFVNIVASE TLNFNDLKGE YLVFRRGHAP DAVKAAVNEG 
841:	GKPLDLETGQ DTQGGDVVKE SPDNEEELNK EYEGIEKGHD IFSWRNLNYD IQIKGEHRRL 
901:	LNGVQGFVVP GKLTALMGES GAGKTTLLNV LAQRVDTGVV TGDMLVNGRG LDSTFQRRTG 
961:	YVQQQDVHIG ESTVREALRF SAALRQPASV PLSEKYEYVE SVIKLLEMES YAEAIIGTPG 
1021:	SGLNVEQRKR ATIGVELAAK PALLLFLDEP TSGLDSQSAW SIVCFLRKLA DAGQAILCTI 
1081:	HQPSAVLFDQ FDRLLLLQKG GKTVYFGDIG EHSKTLLNYF ESHGAVHCPD DGNPAEYILD 
1141:	VIGAGATATT NRDWHEVWNN SEERKAISAE LDKINASFSN SEDKKTLSKE DRSTYAMPLW 
1201:	FQVKMVMTRN FQSYWREPSI LMSKLALDIF AGLFIGFTFY NQGLGVQNIQ NKLFAVFMAT 
1261:	VLAVPLINGL QPKFIELRNV FEVREKPSNI YSWVAFVFSA IIVEIPFNLV FGTLFFLCWF 
1321:	YPIKFYKHIH HPGDKTGYAW LLYMFFQMYF STFGQAVASA CPNAQTASVV NSLLFTFVIT 
1381:	FNGVLQPNSN LVGFWHWMHS LTPFTYLIEG LLSDLVHGLP VECKSHEMLT INPPSGQTCG 
1441:	EYMSAFLTNN TAAGNLLNPN ATTSCSYCPY QTADQFLERF SMRYTHRWRN LGIFVGYVFF 
1501:	NIFAVLLLFY VFRVMKLRST WLGKKITGTG