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3.A.1.205.2
Drug/Sterol/Mutagen exporter, Snq2p

Accession Number:P32568
Protein Name:SNQ2 aka Snq2p aka YDR011W aka YD8119.16
Length:1501
Molecular Weight:168767.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate drugs, sterols, Mutagens

Cross database links:

Genevestigator: P32568
eggNOG: fuNOG04532
HEGENOM: HBG323792
RefSeq: NP_010294.1   
Entrez Gene ID: 851574   
Pfam: PF01061    PF00005    PF06422   
KEGG: sce:YDR011W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005739 C:mitochondrion
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042802 F:identical protein binding
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0042493 P:response to drug
GO:0000304 P:response to singlet oxygen
GO:0006810 P:transport

References (8)

[1] “Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases.”  Servos J.et.al.   8437567
[2] “Sequencing and analysis of a 35.4 kb region on the right arm of chromosome IV from Saccharomyces cerevisiae reveal 23 open reading frames.”  Eide L.G.et.al.   8896275
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[4] “Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.”  Decottignies A.et.al.   7629127
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[8] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSNIKSTQDS SHNAVARSSS ASFAASEESF TGITHDKDEQ SDTPADKLTK MLTGPARDTA 
61:	SQISATVSEM APDVVSKVES FADALSRHTT RSGAFNMDSD SDDGFDAHAI FESFVRDADE 
121:	QGIHIRKAGV TIEDVSAKGV DASALEGATF GNILCLPLTI FKGIKAKRHQ KMRQIISNVN 
181:	ALAEAGEMIL VLGRPGAGCS SFLKVTAGEI DQFAGGVSGE VAYDGIPQEE MMKRYKADVI 
241:	YNGELDVHFP YLTVKQTLDF AIACKTPALR VNNVSKKEYI ASRRDLYATI FGLRHTYNTK 
301:	VGNDFVRGVS GGERKRVSIA EALAAKGSIY CWDNATRGLD ASTALEYAKA IRIMTNLLKS 
361:	TAFVTIYQAS ENIYETFDKV TVLYSGKQIY FGLIHEAKPY FAKMGYLCPP RQATAEFLTA 
421:	LTDPNGFHLI KPGYENKVPR TAEEFETYWL NSPEFAQMKK DIAAYKEKVN TEKTKEVYDE 
481:	SMAQEKSKYT RKKSYYTVSY WEQVKLCTQR GFQRIYGNKS YTVINVCSAI IQSFITGSLF 
541:	YNTPSSTSGA FSRGGVLYFA LLYYSLMGLA NISFEHRPIL QKHKGYSLYH PSAEAIGSTL 
601:	ASFPFRMIGL TCFFIILFFL SGLHRTAGSF FTIYLFLTMC SEAINGLFEM VSSVCDTLSQ 
661:	ANSISGILMM SISMYSTYMI QLPSMHPWFK WISYVLPIRY AFESMLNAEF HGRHMDCANT 
721:	LVPSGGDYDN LSDDYKVCAF VGSKPGQSYV LGDDYLKNQF QYVYKHTWRN FGILWCFLLG 
781:	YVVLKVIFTE YKRPVKGGGD ALIFKKGSKR FIAHADEESP DNVNDIDAKE QFSSESSGAN 
841:	DEVFDDLEAK GVFIWKDVCF TIPYEGGKRM LLDNVSGYCI PGTMTALMGE SGAGKTTLLN 
901:	TLAQRNVGII TGDMLVNGRP IDASFERRTG YVQQQDIHIA ELTVRESLQF SARMRRPQHL 
961:	PDSEKMDYVE KIIRVLGMEE YAEALVGEVG CGLNVEQRKK LSIGVELVAK PDLLLFLDEP 
1021:	TSGLDSQSSW AIIQLLRKLS KAGQSILCTI HQPSATLFEE FDRLLLLRKG GQTVYFGDIG 
1081:	KNSATILNYF ERNGARKCDS SENPAEYILE AIGAGATASV KEDWHEKWLN SVEFEQTKEK 
1141:	VQDLINDLSK QETKSEVGDK PSKYATSYAY QFRYVLIRTS TSFWRSLNYI MSKMMLMLVG 
1201:	GLYIGFTFFN VGKSYVGLQN AMFAAFISII LSAPAMNQIQ GRAIASRELF EVRESQSNMF 
1261:	HWSLVLITQY LSELPYHLFF STIFFVSSYF PLRIFFEASR SAVYFLNYCI MFQLYYVGLG 
1321:	LMILYMSPNL PSANVILGLC LSFMLSFCGV TQPVSLMPGF WTFMWKASPY TYFVQNLVGI 
1381:	MLHKKPVVCK KKELNYFNPP NGSTCGEYMK PFLEKATGYI ENPDATSDCA YCIYEVGDNY 
1441:	LTHISSKYSY LWRNFGIFWI YIFFNIIAMV CVYYLFHVRQ SSFLSPVSIL NKIKNIRKKK 
1501:	Q