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3.A.1.205.21
ABC1 transporter.  Excretes secondary metabolites such as terpenes. Involved in both constitutive and jasmonic acid-dependent induced defense. Secretes the terpenes, sclareol and sclareolide and thereby confers resistance to the fungus, B.cinerea (Stukkens et al. 2005).  Induced by sclareolide and sclareol, and by some phytohormones such as jasmonic acid (JA) and ethylene. Strongly induced by compatible pathogens such as B. cinerea and the bacterium, Pseudomonas syringae pv tabaci, as well as by non pathogenic bacteria such as P. fluorescens, and P. marginalis pv marginalis (Grec et al. 2003).

Accession Number:Q949G3
Protein Name:Pleiotropic drug resistance protein 1
Length:1436
Molecular Weight:161849.00
Species:Nicotiana plumbaginifolia (Leadwort-leaved tobacco) [4092]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sclareolide, Terpenes, Secondary metabolites, Sclareol

Cross database links:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEPADLSNLR GRSLRASIRG SMRGSIRENS NSIWRNNGAE VFSRSARDED DEEALKWAAL 
61:	EKLPTYDRLR KGILFGSQGA AAEVDVDDSG VLERKNLLER LVKVADEDNE KFLLKLKNRI 
121:	DRVGIDFPSI EVRFEHLNID ADAYVGSRAL PTFTNFISNF VEGLLDSIHI LPSKKRQVTI 
181:	LKDVSGIVKP CRMTLLLGPP GSGKTTLLLA LAGKLDSALK VTGKVTYNGH ELHEFVPQRT 
241:	AAYISQHDLH IGEMTVRETL EFSARCQGVG SRYEMLAELS RREKAANIKP DADIDMFMKA 
301:	ASTEGQEAKV VTDYILKILG LDICADTMVG DQMIRGISGG QKKRVTTGEM IVGPSKALFM 
361:	DEISTGLDSS TTYSIVNSLK QSVRIMKGTA LISLLQPAPE TYNLFDDIIL LSDGYIVYEG 
421:	PREEVLEFFE SMGFKCPERK GAADFLQEVT SKKDQQQYWI RRDEPYRFIT SKEFAEAYQS 
481:	FHVGRKVSDE LKTTFDKSKS HPAALTTQKY GIGKRQLLKV CTERELLLMQ RNSFVYLFKF 
541:	FQLLIIALMT MTIFFRTKMP RDSAEDGGIY SGALFFVVIM IMFNGLSELP MTLYKLPVFY 
601:	KQRDFLFYPS WAYAIPSWIL KIPVTFAEVG MWVFLTYYVM GFDPNVGRFF KQFLLLLLVN 
661:	QMASALFRFI AAVGRTMGVA STFGAFALLL QFALGGFILA RNDVKDWWIW GYWTSPLMYS 
721:	VNAILVNEFD GQKWKHIVAG GTEPLGAAVV RARGFFPDAY WYWIGVGALA GFIVMFNIAY 
781:	SVALAYLNPF DKPQATISDE SENNESESSP QITSTQEGDS ASENKKKGMV LPFDPHSITF 
841:	DEVVYSVDMP PEMRESGTSD NRLVLLKSVS GAFRPGVLTA LMGVSGAGKT TLMDVLAGRK 
901:	TGGYIDGSIK ISGYPKKQDT FARISGYCEQ NDIHSPYVTV FESLVYSAWL RLPQDVNEEK 
961:	RMMFVEEVMD LVELTPLRSA LVGLPGVNGL STEQRKRLTI AVELVANPSI IFMDEPTSGL 
1021:	DARAAAIVMR AVRNTVDTGR TVVCTIHQPS IDIFEAFDEL FLMKRGGQEI YVGPLGRQSC 
1081:	HLIKYFESIP GVSKIVEGYN PATWMLEVTA SSQEMALGVD FTDLYKKSDL YRRNKALIDE 
1141:	LSVPRPGTSD LHFDSEFSQP FWTQCMACLW KQHWSYWRNP AYTAVRLIFT TFIALIFGTM 
1201:	FWDIGTKVSR NQDLVNAMGS MYAAVLFLGV QNSSSVQPVV SVERTVFYRE KAAGMYSAIP 
1261:	YAFAQVLIEI PYIFVQATVY GLIVYSMIGF EWTVAKFFWD FFFMFFTFLY FTFFGMMTVA 
1321:	VTPNQNVASI VAGFFYTVWN LFSGFIVPRP RIPIWWRWYY WGCPIAWTLY GLVASQFGDL 
1381:	QDPLTDQNQT VEQFLRSNFG FKHDFLGVVA AVIVAFAVVF AFTFALGIKA FNFQRR