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3.A.1.205.30
Multidrug exporter, AtrF, of 1547 aas and 14 TMSs in a CMCM domain order with a 6 + 6 +2 TMS arrangement. It is a pleiotropic efflux pump that confers resistance to azoles such as fluconazole, voriconazole, and itraconazole (Meneau et al. 2016 Li et al. 2017).

Accession Number:Q4WDD4
Protein Name:ABC multidrug transporter atrF
Length:1547
Molecular Weight:173257.00
Species:Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) [330879]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADGSRLPES ATSTTMETNT NEHAKVLSPD AETVPSSSMT ATSSELSLDG RWGERDQGEP 
61:	VSRRGAMEDF EEMRRELTQL SLRRTRSVGK DAHRLRSRAS GRASQVHDEE KAIDEEDSTI 
121:	DGDGDGYQGG FDLGEFLMGG HLERRTTTGE PAKKVGVLFK HLTVKGVETG ASFVRTLPDA 
181:	VVGTFGPDLY RIVCSFIPQL RFGKQPPVRE LLHDFTGLVR EGEMMLVLGR PGAGCSTFLK 
241:	TIANDRGAFA GVEGEVRYGG LSAEEQLKHF RGEVNYNPED DQHFPSLTVW QTLKFSLINK 
301:	TKKHDKNSIP IIIDALLKMF GITHTKNTLV GNEYVRGVSG GERKRVSIAE TLATKSSVVC 
361:	WDNSTRGLDA STALDYAKSL RIMTDVSKRT TFVTLYQAGE SIYELMDKVL VIDSGRMLYQ 
421:	GPANKAREYF VNLGFHCPEK STTADFLTSI CDPNARQFQP GREASTPKTP EELEAVFRNS 
481:	ETYKTICDEV ASYEKKLQDT DQEDTRRFQK TVAQSKSRTV SKKSSYTVSF ARQVLACVQR 
541:	EFWLLWGDKT SLYTKYFIII SNALIVSSLF YGESLDTSGA FSRGGALFFS ILFLGWLQLT 
601:	ELMPAVTGRG IVARHKEYAF YRPSAVSIAR VVMDFPAIFC MVVPFTIIMY FMTGLDVTAS 
661:	KFFIYFLFVY TTTFSITSLY RMFAALSPTI DDAVRFSGIA LNILVIFVGY VIPKQGLIDG 
721:	SIWFGWLFYV NPIAYSYEAV LTNEFSDRIM DCAPSQLVPQ GPGVDPRYQG CALPGSELGR 
781:	RGVSGSRYLE ESFQFTRSHL WRNFGVVIAF TVLYLIVTVL AAEFLSFVGG GGGALVFKRS 
841:	KRAKKLATQT TQGNDEEKVQ DVGDKAALSR GEAMSASNGE SFKRISSSDR IFTWSNVEYT 
901:	VPYGNGTRKL LNGVNGYAKP GVMIALMGAS GAGKTTLLNT LAQRQKMGVV TGDFLVDGRP 
961:	LGADFQRGTG FCEQMDLHDN TSTIREALEF SALLRQDRNV SKQEKLDYVD QIIDLLELND 
1021:	IQDAIIGSLN VEQKKRVTIG VELAAKPSLL LFLDEPTSGL DSQAAFSIVR FLKKLSLAGQ 
1081:	AILCTIHQPS SMLIQQFDMI LALNPGGNTF YFGPVGHDGG DVIKYFADRG VVCPPSKNVA 
1141:	EFILETAAKA TTTKDGKKID WNEEWRNSEQ NQRVLDEIQQ IREERSKIPV TETGSPYEFA 
1201:	ASTMTQTLLL TKRIFRQYWR DPSYYYGKLF VSVIIGIFNG FTFWMLGNSI ANMQDRMFSI 
1261:	FLIIMIPPVV LNSIVPKFYI NRALWEAREY PSRIYGWFAF CTANIVCEIP MAIVSSLIYW 
1321:	LLWYYPVGFP TDSSTAGYVF LMSMLFFLFM SSWGQWICAF APSFTVISNV LPFFFVMCNL 
1381:	FNGIVRPYRD YPVFWKYWMY YVNPVTWWLR GVISSIFPTV QIDCSPSETT HFNPPPGQTC 
1441:	ANYAGNFITN IAKNGYLLNP DASADCQYCP YSNGAEYMAT LNVHDGDKWR CFGIFLAFVI 
1501:	INWLLVYFFI YTVRVRGWSF GMGYLFGGMG LVIDKVKGVF KRKSEKA