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3.A.1.205.32
MDR exporter, TmrMDR3, of 1503 aas and 12 TMSs in a C-M-C-M domain arrangement. Four ABC transporters (TruMDR1, TruMDR2, TruMDR3, and TruMDR5) and a second MFS transporter (TruMFS2) proved to be able to operate as azole efflux pumps. Milbemycin oxime inhibited only TruMDR3. TruMDR3 transports voriconazole (VRC) and itraconazole (ITC), while TruMDR2 transports only ITC. Disruption of TruMDR3 abolished resistance to VRC and reduced its resistance to ITC (Monod et al. 2019).

Accession Number:F2SG60
Protein Name:ABC multidrug transporter MDR3
Length:1503
Molecular Weight:169082.00
Species:Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus) [559305]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPTEEANVT KPTGELRPDE KLNYEEDVKC SGSSSTTVGK TAYDTDDISQ SQAAELQDLA 
61:	RQLSRASRQG GLDVENEPQQ VINPFLDSES DPELNPDSKS FNVAKWLKTI LQITSRDPER 
121:	FPKRTAGVSF RNMNVHGYGT AADYQSDVGN LPLKAWSGIM SMLGLRKKVR IDILRDFEGL 
181:	VKSGEMLVVL GRPGSGCSTL LRTLSGETHG LYLDEGNDIQ YQGISWEQMH KNFRGEVIYQ 
241:	AETETHFPQM TVGDTLYFAA RARAPANRLP GVSREQYAIH MRSMVMSMLS LSHTINTQVG 
301:	NEYIRGVSGG ERKRISIAET TLSGSPLQCW DNSTRGLDSA NALEFVKSLR LSTKYSGTTA 
361:	IVAIYQAGQA IYDIFDKAVV LYEGHQIYFG NAVRAKEYFI EMGFDCPSRQ TTADFLTSVT 
421:	SPSERRVRPG YESRVPQTPA EFAQRWKESE DRRILMQEID EYNKTYPLHG EQLQKFQASR 
481:	LAEKSRSTSK SSPYTLSYPM EIKLCMWRGF QRLKGDMSMT LTSIIGNIAM SLIIASVFYN 
541:	QQETTDSFFS RGSLLFFAIL MNAFASSLEI LTLWHQRPIV EKHDKYALYH PSSEAISSIL 
601:	VDMPAKLAVA IVFNLIIYFM TNLRRTPGHF FIFFLFSFTT TLTMSNVFRS IAAVSRTLSQ 
661:	ALVPTSIFML ALVIYTGFTI PVRDMRPWFK WISYINPIQY AFESLMINEF HDREFKCAVY 
721:	IPSGPGYSNV SGTSKICAAK GAMAGKPTVS GDVFLRETYS YYASHMWRNY GIIVAFFLFF 
781:	LFVYITATEL VSAKPSKGEI LVFPKGKVPA FLKQSKKKQD PEAASTQEKQ PVETSGHDQT 
841:	AAIVKQTSVF HWESVCYDIK IKKESRRILD NVDGWVKPGT LTALMGVSGA GKTTLLDVLA 
901:	NRVTMGVVTG EMLVDGRLRD DSFQRKTGYV QQQDLHLEIS TVREALTFSA LLRQPNTTPY 
961:	EEKVAYVEEV IKMLGMEEYA NAVVGVLGEG LNVEQRKRLT IGVEIAAKPD LLLFFDEPTS 
1021:	GLDSQTAWSI CTLMRKLADH GQAVLCTIHQ PSAMLMQEFD RLLFLASGGR TVYFGELGKH 
1081:	MSTLIEYFES KGAPKCPPDA NPAEWMLEVI GAAPGSKTDI DWPAVWRDSA ERVEVRRHLA 
1141:	ELKSELSQKP QTPRLTGYGE FAMPLWKQYL IVQHRMFQQY WRSPDYIYSK ACLAIVPTLF 
1201:	IGFTFYKEQV SLQGIQNQMF AIFMFMILFP NLVQQMMPYF VIQRSLYEVR ERPSKTYSWI 
1261:	AFMISSVVVE IPWNALLTVP AFFCWYYPIG FYKNAIPTDA VTERSGTMFL LILIFLMFSS 
1321:	TFSSMVIAGI EQAETGGNIA QLCFSLTLVF CGVLVSPTAM PGFWIFMYRL SPFTYFVSAV 
1381:	LSTGVGRTDI VCAANEILRL TPAAGQTCME YLGPYTKFAG GRILTPDATD MCEFCAVADT 
1441:	DTFLKGVNII FDERWRNIGI LFGYIAFNMV GAIGLYWLLR VPKRKSGVKQ GQQPQKQANE 
1501:	TKA