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3.A.1.205.5
Multidrug resistance protein, Cdr2 (confers resistance to azole and other antifungal agents/terbinafine, amorolfine, aspofungin, etc. as well as a variety of metabolic inhibitors) (Schuetzer-Muehlbauer et al., 2003; Basso et al., 2010). Chimeras between Cdr1 an Cdr2 revealed regions determining substrate specificity (Tanabe et al., 2011). Has an external binding site for an inhibiting octapeptide derivative (Niimi et al., 2012).

Accession Number:P78595
Protein Name:Cdr2
Length:1499
Molecular Weight:168893.00
Species:Candida albicans (Yeast) [5476]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Azoles, Terbinafine, Amorolfine, Aspofungin

Cross database links:

Pfam: PF01061    PF00005    PF06422   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006810 P:transport

References (1)

[1] “Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.”  Sanglard D.et.al.   9043118

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTANTSLSQ QLDENPWVDA SDNSSVQEYQ GFDATASHNI QDLARKLTHG STNGDHHSAN 
61:	DLARYLSHMS DIPGVSPFNG NISHEQLDPD SENFNAKYWV KNLKKLFESD SDYYKPSKLG 
121:	VAYRNLRAYG IANDSDYQPT VTNALWKFTT EAINKLKKPD DSKYFDILKS MDAIMRPGEL 
181:	TVVLGRPGAG CSTLLKTIAV NTYGFHIGKE SQITYDGLSP HDIERHYRGD VIYSAETDVH 
241:	FPHLSVGDTL EFAARLRTPQ NRGEGIDRET YAKHMASVYM ATYGLSHTRN TNVGNDFVRG 
301:	VSGGERKRVS IAEASLSGAN IQCWDNATRG LDSATALEFI RALKTSATIL DTTPLIAIYQ 
361:	CSQDAYELFD NVVVLYEGYQ IFFGKASKAK EYFENMGWKC PQRQTTADFL TSLTNPAERE 
421:	PLPGYEDKVP RTAQEFETFW KNSPEYAELT KEIDEYFVEC ERSNTGETYR ESHVGKQSNN 
481:	TRPSSPYTVS FFMQVRYVIA RNFLRMKGDP SIPLISILSQ LVMGLILASV FFNLRKSTDT 
541:	FYFRGGALFF SVLFNAFSSL LEILSLYEAR PIVEKHRKYA LYRPSADALA SIISELPVKL 
601:	LMTMSFNIVY YFMVNLRRTA GNFFFYWLMC ASCTLVMSHM FRSIGAVTTT IATAMSLSTV 
661:	FLLAMIIYAG FVLPIPYILG WSRWIRYINP VTYIFESLMV NEFHGREFEC GQYIPSGPGF 
721:	ENLPVENKVC TTVGSTPGST VVQGTEYIKL AYQFYSSHKW RNFGITVAFA VFFLGVYVAL 
781:	TEFNKGASQK GEIVLFLKGS LKKHKRKTAA SNKGDIEAGP VAGKLDYQDE AEAVNNEKFT 
841:	EKGSTGSVDF PENREIFFWR DLTYQVKIKK EDRVILDHVD GWVKPGQITA LMGASGAGKT 
901:	TLLNCLSERV TTGIITDGER LVNGHALDSS FQRSIGYVQQ QDVHLETTTV REALQFSAYL 
961:	RQSNKISKKE KDDYVDYVID LLEMTDYADA LVGVAGEGLN VEQRKRLTIG VELVAKPKLL 
1021:	LFLDEPTSGL DSQTAWSICK LMRKLADHGQ AILCTIHQPS ALIMAEFDKL LFLQKGGRTA 
1081:	YFGELGENCQ TMINYFEKYG ADPCPKEANP AEWMLQVVGA APGSHAKQDY FEVWRNSSEY 
1141:	QAVREEINRM EAELSKLPRD NDPEALLKYA APLWKQYLLV SWRTIVQDWR SPGYIYSKLI 
1201:	LVISSSLFIG FSFFKSKNNL QGLQSQMLAV FMFFVPFTTF IDQMLPYFVK HRAVYEVREA 
1261:	PSRTFSWFAF IAGQITSEIP FQIVVGTISY FCWYYPVGLY ANAEPTDSVN SRGVLMWMLL 
1321:	TAFYVYTSTM GQLAISLNEL IDNAANLATT LFTLCLMFCG VLAGPNVIPG FWIFMYRCNP 
1381:	FTYLIQAILS TGLANAKVTC APRELVTLKP PMGETCSSFI GPYTEAAGGY FSTNSDGTCS 
1441:	VCRIDSTNQF LESINALFSQ RWRNFGIFVA FIGINIILTI FFYWLARVPK GNREKKMKK