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3.A.1.205.6
Multidrug resistance protein, Cn Afr1 (confers resistance to azole antifungal drugs including fluconazole) (Posteraro et al., 2003)

Accession Number:Q8X0Z3
Protein Name:CNAFR1 aka CDR1 aka AFR1
Length:1543
Molecular Weight:172627.00
Species:Cryptococcus neoformans (Filobasidiella neoformans) [5207]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Azoles, Fluconazole

Cross database links:

Pfam: PF01061    PF00005    PF06422   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006810 P:transport

References (1)

[1] “Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole.”  Posteraro B.et.al.   12519188

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSATGVPAEL NNLGAPITAT TQNPSGLANS QVTSGPASSA TQHDEHRSSA GNTLADEEND 
61:	KAVESEKAEV IDAAADGKQK RLAADSSENI VTELEPHHVS IHRGKEEFAA LERRYSTLSQ 
121:	QSQHELHRPT TRHSVRSSFS RKDRVVSRLT QDDAEKAKEG EGEFNLVDVL RSGRENQDEA 
181:	GIKRKAVGVI WEDLEVIGAG GMRINIRNFS SAIIEQFMMP AFKILSIFGV NPFAPKPKAI 
241:	LHPSSGLLKP GEMCLVLGRP GAGCTTFLKT ITNQRAGFME IKGNVEYAGV GWKEMRKRYG 
301:	GEVVYNQEDD DHLPTLTVAQ TIRFAPATKT PKKKIPGVSA KQFQDDMLDL LLSMLNIKHT 
361:	ANTIVGNAYV RGVSGGERKR VSIAEMFCSG ATVCSWDNST RGLDASTALD YAKSLRLLTD 
421:	IMGQTTFVSL YQAGEGIYDQ FDKVLVLNEG HVAYFGPAKE ARQYMIGLGY RDLPRQTTAD 
481:	YLSGCTDVNE RRFADGRDET NVPATPEEMD KAYKESEVCA RMTREREEYK QLMAEDATAR 
541:	EDFRQAVLEQ KHKGVSKKSP YTVSFLQQVF IIFKRQLRLK FQDHFGISTG YATAIISALI 
601:	VGSVYFRLPE TASGAFTRGG LLFLGLLFNA LTSFSELPSQ MLGRSVLYRQ NEYRFYRPAA 
661:	FALAAVLADV PYNASVIFLF SIVLYFMGGL YSSGGAFFMF FLFVFLTFMV MSAFFRTLGV 
721:	ATSDYNVAAR LASVLISFMV TYTGYMIPVQ RMKRWLFWIF YLNPLSYGYE AIFANEFSRI 
781:	NLTCDSSYTI PRNIPEAGIT GYPDTLGPNQ MCSIFGSTPG DPNVSGSDYM ATGYSYYKAH 
841:	IWRNFGILLG FFAFFMFLQM LFIEVLEQGA KHFSINVYKK EDKDLKAKNE RLAERLEAFR 
901:	AGELEQDLSE LKMRPEPFTW EVLNYTVPVP GGHRQLLNDI YGYVKPGSLT ALMGASGAGK 
961:	TTVLDVRASR KNIGVIEGDV LMNGRPIGTG FQRGCGYAEQ QDTHEWTTTV REALRYSAYL 
1021:	RQPQHVPKQE KDDYVEDIIE LLELQELADA MIGFPGYGLS VEARKRVTIG VELAAKPELL 
1081:	LFLDEPTSGL DGQSAYNIVR FLKKLCAAGQ KILCTIHQPN ALLFQSFDRL LLLQRGGECV 
1141:	YFGDIGPDSK VLIDYLERNG AKVPHDANPA EFMLEAIGAG SRKRIGSDWG EKWRNSPEFA 
1201:	EVKREIQELK AEALAKPVEE KSNRTEYATS FFFQLKTVLR RTNVALWRNA DYQWTRLFAH 
1261:	LAIGLIVTLT FLQLDNSVQS LQYRVFAIFF ATVLPALILA QIEPQYIMSR MTFNREASSK 
1321:	MYSSTVFALT QLLSEMPYSL GCAVSFFLLL YYGVGFPYAS SRAGYFFLMI LVTEVYAVTL 
1381:	GQAVAALSPT ILIAALFNPF LLVLFSIFCG VTAPPPTLPY FWRKWMWPLD PFTRLISGLV 
1441:	STVLQDQEVV CKDGEYQVFP APSGQTCQQW AGAFAEAIGG YINNPDSTGD CQFCQYRTGQ 
1501:	AFFTPLEISF STRWRDFGIF ICYVVFNILV LLIAARFLKW QRR