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3.A.1.205.7
The multidrug resistance protein, AtrB (confers resistance to all major classes of fungicides as well as natural toxic compounds substrates include: anilinopyrimidine, benzimidazole, phenylpyrrole, phenylpyridylamine, strobirulin, azoles, dicarboximides, quintozene, acriflavin, and rhodamine 6G as well as natural toxins such as camptothecin (an alkaloid) and the stilbene phytoalexin, resveratrol) (Andrade et al., 2000).

Accession Number:P78577
Protein Name:AtrB
Length:1426
Molecular Weight:158928.00
Species:Aspergillus nidulans [162425]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate Fungicides, Anilinopyrimidine, Benzimidazole, Phenylpyrrole, Phenylpyridylamine, Strobirulin, Azoles, Dicarboximides, Quintozene, acriflavin, Rhodamine 6G, camptothecin, Resvertrol

Cross database links:

Pfam: PF01061    PF00005    PF06422   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006810 P:transport

References (2)

[1] “Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters.”  Del Sorbo G.et.al.   9180695
[2] “The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds.”  Andrade A.C.et.al.   10931903

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTLTVGDTA LPRESRETMV SIQGIRIVNY SSRRGFRFHN KIQMSAVPMA GLLMPQVKEQ 
61:	NEREAESGFK RRELGVTWQN LSVEVVSADA AVQENFLSQF NVPKLARESR NKPPLRTILD 
121:	NSHGCVKPGE MLLVLGRPGS GCTTLLKMLA NQRLGYKAVQ GDVRYGSMTA KEAEQYRGQI 
181:	VMNTQEELFF PSLTVGETMD FATRLKVPNR LPNGVESPEA YREEYKKFLL QSMGISHTVD 
241:	TKVGNEFIRG VSGGERKRVS IIECLGTRAS VFCWDNSTRG LDASTALEWT KTIRTMTDVL 
301:	GLSTIVTLYQ AGNGIYDLFD KVLVLDEAKQ IYYGPMTQAR PYMETLDFVC REGSNVADFL 
361:	TGVTVPTERK IRSGFEARFP RNADAMLEEY NKSAVKADMI SEYDYPDSEY AKLRTEDFKQ 
421:	AIAEEKAKQL PKSSPFTVDF MNQVKICVTR QYQILWGDKA TFIIKQVSTL IQALIAGSLF 
481:	YDAPNNSGGL FVKSGALFFS LLYNSLLAMA EVTESFQGRP VLIKHKSFAF FHPAAFCIAQ 
541:	IAADIPVLIF QVTIFALPVY FMVGLEMDAG VFFTYWILVF ATTMAMTAVF RACGAAFKTF 
601:	DDASKVSGFL ISALIMYTGY MIRKPEMHPW FVWIYWIDPL AYGFDALLSN EFHGKIIPCV 
661:	GTNLVPAGPG YENATTQSCT GVGGSIPGRN YVTGDDYLAS LSYSHGHVWR NFGILWAWWA 
721:	LFVVVTIIAT SRWKGASENG PSLLIPRESV EKHRQHGHRD EESQSNEKTS TKGKSEGVQD 
781:	SSDIDNQLVR NTSVFTWKDL CYTVKTPSGD RQLLDHVYGW VKPGMLGALM GSSGAGKTTL 
841:	LDVLAQRKTA GTIQGSVLVD GRPLPVSFQR SAGYCEQFDV HEPYATVREA LEFSALLRQP 
901:	RTTPREEKLK YVDVIIDLLE LHDIADTLIG RVGAGLSVEQ RKRVTIGVEL VSKPSILIFL 
961:	DEPTSGLDGQ SAYNTVRFLR KLADVGQAVL VTIHQPSAQL FGEFDSLLLL AKGGKMVYFG 
1021:	DIGDNGSTVK EYFGRHGAPC PPNANPGEHM IDVVSGSLSQ GRDWHEVWKA SPEHTNAQKE 
1081:	LDRIISEAGS KPPGTVDDGH EFAMPLWQQT VIVTKRTCLG VYRNTDYVNN KLALHIGSAL 
1141:	FNGFSFWKMG ASVGELQFKL FVLFNFIFAA PGGIGQVQAL FIERRDIYDA REKKSRIFSW 
1201:	VGFVTGLIVS ELPYLVLCAV LYFVCFYYQT GLPTSSDKAG AVFFVMLLYE GLYTGIGQFI 
1261:	SAYAPNAVFA TLTNPLVIGT LVSFCGVLVP YGQIQEFWRY WIYWLNPFNY LMGSLLTFTI 
1321:	FDVDIKCRES EFATFDPPNG SSCIDYLSTI FKGWGVSANL INPDATSQCQ VCQYTRGSDY 
1381:	LYSLNLKDYY YGWRDTAIVA LFVLSSYALV YGLMKLRTKA SKKAEE