TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.205.8
The multidrug resistance protein, Pdr11p, mediates sterol uptake by promoting movement of sterols from the plasma membrane to the endoplasmic reticulum where esterification occurs (Li and Prinz, 2004).

Accession Number:P40550
Protein Name:ATP-dependent permease PDR11
Length:1411
Molecular Weight:160538.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate sterols, drugs

Cross database links:

Genevestigator: P40550
eggNOG: KOG0065
HEGENOM: HBG323792
DIP: DIP-8310N
RefSeq: NP_012252.1   
Entrez Gene ID: 854802   
Pfam: PF01061    PF00005    PF06422   
KEGG: sce:YIL013C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0015918 P:sterol transport

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.”  Churcher C.M.et.al.   9169870
[2] “Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.”  Decottignies A.et.al.   7629127
[3] “Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.”  Wilcox L.J.et.al.   12077145
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS DITFRANEGE 
61:	VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ FASKCPHQII YNNEQDIHFP 
121:	YLTVEQTIDF ALSCKFHIPK QERIEMRDEL LKEFGLSHVK KTYVGNDYVR GVSGGERKRI 
181:	SIIETFIANG SVYLWDNSTK GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF 
241:	DKILMLGDSF QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL 
301:	DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV NPDDISPIFS 
361:	IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG SLFYNIPLTT IGSFSRGSLT 
421:	FFSILFFTFL SLADMPASFQ RQPVVRKHVQ LHFYYNWVET LATNFFDCCS KFILVVIFTI 
481:	ILYFLAHLQY NAARFFIFLL FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY 
541:	ASYVIYMKDM HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH 
601:	KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS LLAAEYITPL 
661:	FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP KTPIANFSTS SSSVPSVSHQ 
721:	YDTDYNIKHP DETVNNHTKE SVAMETQKHV ISWKNINYTI GDKKLINDAS GYISSGLTAL 
781:	MGESGAGKTT LLNVLSQRTE SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV 
841:	RESLEISCVL RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF 
901:	LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL LKRGGECVYF 
961:	GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN IPMDDAEKPT SSKIDEPVSY 
1021:	HKQSDSINWA ELWQSSPEKV RVADDLLLLE EEARKSGVDF TTSVWSPPSY MEQIKLITKR 
1081:	QYICTKRDMT YVFAKYALNA GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ 
1141:	VQDKALQSKE VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA 
1201:	RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG VMQPYSLFPR 
1261:	FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP VMGQTCGQFM KPFIDEFGGK 
1321:	LHINNTYTVC AYCMYTVGDD FLAQENMSYH HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK 
1381:	KIWPSVIDGI KKCIPSMRRS KTSHNPNEQS V