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3.A.1.208.48
Multidrug resistance protein, MRP4 or ABCC4, of 1349 aas and 12 TMSs in an M-C-M-C domain order. The non-steroidal anti-inflammatory drug (NSAID) diclofenac, known to cause hyperuricemia and concomitant visceral gout in Gyps vultures may be a result of interference with renal uric acid excretion. Three species of Gyps vultures are on the verge of extinction due to nephrotoxic veterinary diclofenac having entered the food chain, and because the toxicity of different avian species to the NSAIDs like diclofenac varies. MRP4, an organic anion transporter in birds, plays a unique role in unidirectional efflux of urate into the proximal renal tubular lumen for excretion and maintenance of homeostasis. Barik et al. 2019 characterized the MRP4 channel at the molecular level to predict its structural based ligand binding properties in Gallus domesticus (Indian domestic chicken) and Gyps himalayensis (the Himalayan griffon vulture)including point and insertional mutational variants.

Accession Number:AON76441
Protein Name:AON76441.1 multidrug resistance protein 4 [Gyps himalayensis]
Length:1350
Molecular Weight:
Species:Gyps himalayensis [36248]
Number of TMSs:11
Substrate

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FASTA formatted sequence
1:	MEAVPREEKP NPLRDANLCS RLFFWWLNPL FIIGHKRKLE EDDMYKVLPE DSSKKLGEDL 
61:	QWYWDKEVQK AKKRGKTPHL TKAIILCYWK SYLVLGIFTM IEETLKIVQP IFLGKIITYF 
121:	ENYDASDEVA LNVAYCYAAA LSVCTLILAI MHHLYFYHVQ RAGMKLRVAM CHMIYRKALR 
181:	LSNVAMAKTT TGQIVNLLSN DVNKFDQVTI FLHFLWAGPI QAVAVTVLLW MEIGPSCLAG 
241:	MAVLIILLPI QTCIGRLFSS LRSKTAALTD VRIRTMNEVI SGMKIIKMYA WEKSFAELVS 
301:	GLRRKEIAMV LKSSYLRGLN LASFFVASKI TVFMTFMAYV LLGNVISASR VFVAVSLYGA 
361:	VRLTVTLFFP SAVERVSEAV VSIRRIKNFL ILDEVSHFKP QLHDNNENVI LHVQDLTCYW 
421:	DKSLESPALQ QLSFTVRQGE LLAVIGPVGA GKSSLLSAVL GELPKEKGLI NVSGRIAYVS 
481:	QQPWVFSGTV RSNILFDKEY EREKYEKVLK VCALKKDLDL LANGDLTVIG DRGATLSGGQ 
541:	KARVNLARAV YQDADIYLLD DPLSAVDAEV GRHLFEKCIC QALHQKICVL VTHQLQYLRA 
601:	ATQILILKDG KMVGKGTYSE FLRSGIDFAS LLKKEEEVEQ PSVPGTPNLK SSRSRTFSES 
661:	SVWSQDSSIH SVKDGAVEQP PTENALAAVP EESRSEGKIS FKVYRKYFTA GANYFVIFIL 
721:	VLFNILAQVA YVLQDWWLSY WANHQGKLNV TTNGNNGANE TEHLDLAFYL GIYAGLTVAT 
781:	ILFGIIRSLL VFQVLVNSGQ TLHNKMFKSI LKAPVLFFDR NPIGRILNRF SKDIGHLDDL 
841:	LPLTFLDFVQ TLLQIFGVVA VAVAVIPWIL IPLIPLFILF IFLRRYFLDT SRDIKRLEST 
901:	TRSPVFSHLS SSLQGLWTIR ALKAEDRFQK LFDAHQDLHS EAWFLFLTTS RWFAVRLDAI 
961:	CAIFVIVVAF GSLLLAKTLN AGQVGLALSY AITLMGTFQW GVRQSAEVEN LMISVERVME 
1021:	YTDLEKEAPW ETNKHPPPEW PSHGMIAFEN VNFTYSLDGP LVLRHLSVVI KPEEKQSLLH 
1081:	TSESQAVGNC PLVSVGIVGR TGAGKSSLIA ALFRLAEPEG RIWIDKYLTS ELGLHDLRKK 
1141:	ISIIPQEPVL FTGTMRKNLD PFNEYTDEEL WNALEEVQLK EAVEDLPNKM ETQLAESGSN 
1201:	FSVGQRQLVC LARAVLKKNR ILIIDEATAN VDPRTDEFIQ KTIREKFAHC TVLTIAHRLN 
1261:	TIIDSDRIMV LDAGRLKEYG EPYILLQEKD GLFYKMVQQV GKTEAASLME TAKRVYFRKN 
1321:	YPEVVQNGQL ATDSSLDPSS GLCITETAL