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3.A.1.210.1
The mitochondrial iron transporter, ATM1.  The crystal structures of the nucleotide-free and glutathione-bound inward facing, open conformations have been solved at 3.1 and 3.4 Å resolution respectively (Srinivasan et al. 2014).  The glutathione binding site is near the inner membrane surface in a large cavity.  An unknown sulfur compound appears to be exported by Atm1 and used for the synthesis of iron/sulfur centers in the cytoplasm.  This compound also signals iron sufficiency/deficiency to the nucleus (Philpott et al. 2012). [But see also, 3.A.210.15].

Accession Number:P40416
Protein Name:ATM1 aka MDY aka YMR301C aka YM9952.03C
Length:690
Molecular Weight:77522.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Fe2+

Cross database links:

Genevestigator: P40416
eggNOG: fuNOG05804
HEGENOM: HBG758042
RefSeq: NP_014030.1   
Entrez Gene ID: 855347   
Pfam: PF00664    PF00005   
KEGG: sce:YMR301C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006879 P:cellular iron ion homeostasis
GO:0006826 P:iron ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast.”  Leighton J.et.al.   7828591
[2] “The ABC transporter Atm1p is required for mitochondrial iron homeostasis.”  Kispal G.et.al.   9428742
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.”  Bowman S.et.al.   9169872
[4] “The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins.”  Kispal G.et.al.   10406803
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “The mitochondrial ABC transporter Atm1p functions as a homodimer.”  Chloupkova M.et.al.   15225610
Structure:
4MYC   4MYH     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLLLPRCPVI GRIVRSKFRS GLIRNHSPVI FTVSKLSTQR PLLFNSAVNL WNQAQKDITH 
61:	KKSVEQFSSA PKVKTQVKKT SKAPTLSELK ILKDLFRYIW PKGNNKVRIR VLIALGLLIS 
121:	AKILNVQVPF FFKQTIDSMN IAWDDPTVAL PAAIGLTILC YGVARFGSVL FGELRNAVFA 
181:	KVAQNAIRTV SLQTFQHLMK LDLGWHLSRQ TGGLTRAMDR GTKGISQVLT AMVFHIIPIS 
241:	FEISVVCGIL TYQFGASFAA ITFSTMLLYS IFTIKTTAWR THFRRDANKA DNKAASVALD 
301:	SLINFEAVKY FNNEKYLADK YNGSLMNYRD SQIKVSQSLA FLNSGQNLIF TTALTAMMYM 
361:	GCTGVIGGNL TVGDLVLINQ LVFQLSVPLN FLGSVYRDLK QSLIDMETLF KLRKNEVKIK 
421:	NAERPLMLPE NVPYDITFEN VTFGYHPDRK ILKNASFTIP AGWKTAIVGS SGSGKSTILK 
481:	LVFRFYDPES GRILINGRDI KEYDIDALRK VIGVVPQDTP LFNDTIWENV KFGRIDATDE 
541:	EVITVVEKAQ LAPLIKKLPQ GFDTIVGERG LMISGGEKQR LAIARVLLKN ARIMFFDEAT 
601:	SALDTHTEQA LLRTIRDNFT SGSRTSVYIA HRLRTIADAD KIIVLDNGRV REEGKHLELL 
661:	AMPGSLYREL WTIQEDLDHL ENELKDQQEL