TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.210.2
The vacuolar heavy metal tolerance protein precursor, HMT1 (transports phytochelins and Cd2+·phytochelin complexes) (Prévéral et al., 2009).

Accession Number:Q02592
Protein Name:HMT1 aka SPCC737.09C aka SPCC74.08C
Length:830
Molecular Weight:93994.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Cd2+-phytochelin, Phytochelins

Cross database links:

eggNOG: fuNOG06778
HEGENOM: HBG758042
RefSeq: NP_588371.3   
Entrez Gene ID: 3361134   
Pfam: PF00664    PF00005   
KEGG: spo:SPCC737.09c   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0015086 F:cadmium ion transmembrane transporter activity
GO:0070574 P:cadmium ion transmembrane transport
GO:0046686 P:response to cadmium ion

References (2)

[1] “Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter.”  Ortiz D.F.et.al.   1396551
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVLRYNSPRL NILELVLLYV GFFSIGSLNL LQKRKATSDP YRRKNRFGKE PIGIISWWIL 
61:	GIALTYVVDI SNLVIYALRV PNWWPCKTTV VCLILFLLFW IIVLISCADS KALPKNADSI 
121:	LKAYRLSVLY VWAIDIVFET IFIVYSPHPN ETFQGIVLAD HVARLVLCVF ATAIYLTYRR 
181:	KRHTHDPLDF EERQLTEESN VNENAISQNP STVQLGVSAS TSNFGTLKST SKKPSDKSWA 
241:	EYFRSFSTLL PYLWPTKDYR LQFQIFICIV LLFLGRAVNI LAPRQLGVLT EKLTKHSEKI 
301:	PWSDVILFVI YRFLQGNMGV IGSLRSFLWV PVSQYAYRAI STKALRHVLN LSYDFHLNKR 
361:	AGEVLTALTK GSSLNTFAEQ VVFQIGPVLL DLGVAMVYFF IKFDIYFTLI VLIMTLCYCY 
421:	VTVKITSWRT EARRKMVNSW RESYAVQNDA IMNFETVKNF DADDFENERY GHAVDIYLKQ 
481:	ERKVLFSLNF LNIVQGGIFT FSLAIACLLS AYRVTFGFNT VGDFVILLTY MIQLQQPLNF 
541:	FGTLYRSLQN SIIDTERLLE IFEEKPTVVE KPNAPDLKVT QGKVIFSHVS FAYDPRKPVL 
601:	SDINFVAQPG KVIALVGESG GGKSTIMRIL LRFFDVNSGS ITIDDQDIRN VTLSSLRSSI 
661:	GVVPQDSTLF NDTILYNIKY AKPSATNEEI YAAAKAAQIH DRILQFPDGY NSRVGERGLK 
721:	LSGGEKQRVA VARAILKDPS IILLDEATSA LDTNTERQIQ AALNRLASGR TAIVIAHRLS 
781:	TITNADLILC ISNGRIVETG THEELIKRDG GAYKKMWFQQ AMGKTSAETH