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3.A.1.210.5
Multidrug resistance homologues, Pfmdr2, protein

Accession Number:Q25693
Protein Name:Pfmdr2
Length:1025
Molecular Weight:119153.00
Species:Plasmodium falciparum [5833]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (1)

[1] “Plasmodium falciparum: the pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasite.”  Rubio J.P.et.al.   7914495

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDVSNYEYLR SYGIKNELKR KRTHKKIIIY HLLDIIIFFL LFFSCYNFNL ELCYKYEKAI 
61:	FYNFFKSSVD LFLLNVIRII YTVILFRLHK KLTELNTLGK VYVLSRHITG ILVILNVIKM 
121:	INYSYVIKSE NPLYNTNMYL ITLKVLFMVY SMISSIYYYF IQFKLYNIKK KYIIARVELE 
181:	KILINDIKSK KYNIYKSDEN SGLLGTDNNS TIMNNEYLNL DYKNLLDMNI SYNKLNEKIN 
241:	NDIINNTSDV QEKNMDYNDI HNFQKKKKSS NFAYLNFFHK ESKDNKIDVK ESFLNKRYGS 
301:	NKRSSKIYDN NNNNNNNNNI NSKIDYLENN ITYTEFKKIL LPYLWPSKRI DMKGNSSILR 
361:	TYIVLIFLFI LVSKVFSVIS PIYLGWASNE VLKKSLSSSV YYLGLYVTFF FISKFLKEVC 
421:	GVLFSQVQQS AFIELQESIF QTFHNLSYEW YSSKNSGGIM RIVDRGTESA NNLMSSVLMY 
481:	IIPATIEGLI TCIIFIFKYK NSLLGSVLFI GLTLYIYSTI KITKWRKKIR TKANEMDNVY 
541:	HDIAHDSLTN YENVKYFSNE KFEIKKFCNA LSNYHRYNLK ILNSLGILNT VQQFILNGTL 
601:	FFTLLCVIYM IVKEGSDPGT FISVVVYTSN VFAPLSILGT LYATIIKSFT DISDLIDILR 
661:	DKIDISNDKN LKNFDLTSQE KKFGVSIEFN NVHFNYPTQP LHTSLKDINI YIKPGTTCAL 
721:	VGHTGSGKTT ISKLLYRFYD SKGEIKIGGR NINEYTRNSI RNIIGIVPQD TILFNESIKY 
781:	NILYGKLDAT EEELIQAVKS AQLYDFIQSL PKKWDTLVGD KGVKLSGGER QRISIARCLL 
841:	KDPKIVIFDE ATSSLDSRTE YLFQKAVEDL RKNRTIIIIA HKLCTITTAE LIILLNKGKI 
901:	IERGTHLDLL KCNGEYTEMW NMQSKSNEPH TETNSSIDKD DVNKNNNKNN DVILNTCKND 
961:	ITTSFRSNSE KSSQEFSDAS NHIKQSKTSN DHNNNINVHK KNEQEQLFLT NDKTDMDDNM 
1021:	NNKKK