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3.A.1.210.6
Mitochondrial outer membrane/lysosome anionic porphyrin uptake half ABC transporter, ABCB6. Expressed in many mammalian tissues (including fetal liver) in response to intracellular porphyrin. Porphyrin uptake activates de novo porphyrin (haem) biosynthesis (Krishnamurthy et al., 2006).  The first TMS contains a lysosomal targetting signal (Kiss et al. 2015).

Accession Number:Q9NP58
Protein Name:ABCB6 aka MTABC3
Length:842
Molecular Weight:93886.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1 / Multi-pass membrane protein2
Substrate Anionic porphyrins, Porphyrins

Cross database links:

Genevestigator: Q9NP58
eggNOG: prNOG16479
RefSeq: NP_005680.1   
Entrez Gene ID: 10058   
Pfam: PF00664    PF00005   
OMIM: 605452  gene
KEGG: hsa:10058   

Gene Ontology

GO:0043190 C:ATP-binding cassette (ABC) transporter complex
GO:0016021 C:integral to membrane
GO:0005741 C:mitochondrial outer membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006879 P:cellular iron ion homeostasis
GO:0055085 P:transmembrane transport

References (7)

[1] “MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis.”  Mitsuhashi N.et.al.   10837493
[2] “Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6.”  Emadi-Konjin H.-P.et.al.   11955620
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Identification of a mammalian mitochondrial porphyrin transporter.”  Krishnamurthy P.C.et.al.   17006453
[6] “Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6.”  Kurashima-Ito K.et.al.   16791740
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
Structure:
3NH6   3NH9   3NHA   3NHB     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVTVGNYCEA EGPVGPAWMQ DGLSPCFFFT LVPSTRMALG TLALVLALPC RRRERPAGAD 
61:	SLSWGAGPRI SPYVLQLLLA TLQAALPLAG LAGRVGTARG APLPSYLLLA SVLESLAGAC 
121:	GLWLLVVERS QARQRLAMGI WIKFRHSPGL LLLWTVAFAA ENLALVSWNS PQWWWARADL 
181:	GQQVQFSLWV LRYVVSGGLF VLGLWAPGLR PQSYTLQVHE EDQDVERSQV RSAAQQSTWR 
241:	DFGRKLRLLS GYLWPRGSPA LQLVVLICLG LMGLERALNV LVPIFYRNIV NLLTEKAPWN 
301:	SLAWTVTSYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRRVELLIF SHLHELSLRW 
361:	HLGRRTGEVL RIADRGTSSV TGLLSYLVFN VIPTLADIII GIIYFSMFFN AWFGLIVFLC 
421:	MSLYLTLTIV VTEWRTKFRR AMNTQENATR ARAVDSLLNF ETVKYYNAES YEVERYREAI 
481:	IKYQGLEWKS SASLVLLNQT QNLVIGLGLL AGSLLCAYFV TEQKLQVGDY VLFGTYIIQL 
541:	YMPLNWFGTY YRMIQTNFID MENMFDLLKE ETEVKDLPGA GPLRFQKGRI EFENVHFSYA 
601:	DGRETLQDVS FTVMPGQTLA LVGPSGAGKS TILRLLFRFY DISSGCIRID GQDISQVTQA 
661:	SLRSHIGVVP QDTVLFNDTI ADNIRYGRVT AGNDEVEAAA QAAGIHDAIM AFPEGYRTQV 
721:	GERGLKLSGG EKQRVAIART ILKAPGIILL DEATSALDTS NERAIQASLA KVCANRTTIV 
781:	VAHRLSTVVN ADQILVIKDG CIVERGRHEA LLSRGGVYAD MWQLQQGQEE TSEDTKPQTM 
841:	ER