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3.A.1.210.7
The homodimeric heavy metal tolerance protein 1, CeHMT-1 (AbcB6) (exports phytochelatin ((γ-Glu-Cys)n)-Cd2+ complexes as well as glutathione complexes of copper and arsenic) (Vatamaniuk et al., 2005).  The N-terminal hydrophobic extension domain is required (but not sufficient) for dimerization and therefore is essential for normal function (Kim et al. 2010, Kim et al. 2018). Both the N- and C-terminal domains are required for proper localization in the endosomes of liver-like coelomocytes, head neurons and intestine (Kim et al. 2018).

Accession Number:Q9XUJ1
Protein Name:Hypothetical protein hmt-1 (Heavy metal tolerance factor 1)
Length:801
Molecular Weight:90575.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cd2+-phytochelatin

Cross database links:

RefSeq: NP_001022812.1   
Entrez Gene ID: 176540   
Pfam: PF00664    PF00005   
KEGG: cel:W09D6.6   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (2)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.”  Vatamaniuk O.K.et.al.   15840570

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGFSPFLDEC RAEGLWPIGP SCNKIISFGV YTFFIVVNFI VLCIPNSNSA NNNYRRMTDD 
61:	DASSTSKLTI SKILSICTIF AVICQSIFYF CFTFYFHPYT HLLLAFCVSK LFFWILSLCS 
121:	FSKWRNQPST PISLAFAFSA ALLIHCIPLT DWKKYFEPTS KNRGDLTFYI IELALVTVVF 
181:	FFTIVTGLFN FSGCSSRESA WNNLSKKVVT VAPYIWPTKS ISLQLRVVFC LFLLIIGRLI 
241:	NVSLPILSKW IVDELATPDT FQYSLLFLAT FLKFLQGNGA MGGFLNTVRT YLWIPIQQYT 
301:	TRELEVELFK HLHSLSLRWH LSRKTGQVLR VMDRGTSSVN NILNYILFNV VPTIADIVIA 
361:	VIFFFSAFNA YFGLIVFGTM ALYLTVTISI TEWRTQYIRE ANEKDNATSA IATDSLINYE 
421:	TVKYYGNEEF EVNRFKNAIE SYQVTEWKTQ ASLAFLNCLQ NAIIGIGMIG GSVFVVYMIV 
481:	HEKTLTVGDY VLFTTYLLQL YTPLNFFGTI YRVIQKAFVD MENMFDLMND EVEVKDLPHA 
541:	LPYTDPRGTI SVKNLTFEYN TGLPVIKNIS FEIGNGQTVA LVGSSGSGKS TLIRLLFRLF 
601:	ESTEGSIEFD GIDVRNYTMH SLRQQIGIVP QDTVLFNDTI MYNIRFGRPD ASDEEVIEAA 
661:	KAAMIHEKIT SLPEGYATMV GERGLKLSGG EKQRVAIART ILKKPQFIFL DEATSALDTP 
721:	TERAIQKCLE KLCKSRTGVV VAHRLSTVVN ADLILVLDKG IILERGNHKE LLAQQGTYAS 
781:	MWEAQIAEQR AKSIELGEEL P