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3.A.1.210.8
Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively.  It may function in cytosolic iron-sulfur cluster biogenesis (Bernard et al. 2009) as well as molybdenum cofactor biosynthesis (Teschner et al. 2010).  It performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors. Not required for mitochondrial and plastid Fe-S enzymes. Probably involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol. Mediates glutathione-dependent resistance to heavy metals such as cadmium and lead, as well as their transport from roots to leaves. Regulates nonprotein thiols (NPSH) and the cellular level of glutathione (GSH).

Accession Number:Q9LVM1
Protein Name:ABC transporter-like protein aka ATM3
Length:728
Molecular Weight:80420.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Fe2+, Metal ions, cPMP

Cross database links:

Genevestigator: Q9LVM1
RefSeq: NP_200635.1   
Entrez Gene ID: 835939   
Pfam: PF00664    PF00005   
KEGG: ath:AT5G58270   

Gene Ontology

GO:0009941 C:chloroplast envelope
GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006879 P:cellular iron ion homeostasis
GO:0009658 P:chloroplast organization
GO:0006826 P:iron ion transport
GO:0009555 P:pollen development
GO:0050790 P:regulation of catalytic activity
GO:0010380 P:regulation of chlorophyll biosynthetic process
GO:0046686 P:response to cadmium ion
GO:0010288 P:response to lead ion
GO:0048364 P:root development
GO:0055085 P:transmembrane transport

References (11)

[1] “A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik.”  Kushnir S.et.al.   11158531
[2] “Functional characterization of AtATM1, AtATM2, and AtATM3, a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis.”  Chen S.et.al.   17517886
[3] “Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10718197
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[6] “Multifunctionality of plant ABC transporters -- more than just detoxifiers.”  Martinoia E.et.al.   11855639
[7] “The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions.”  Brugiere S.et.al.   15276431
[8] “Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins.”  Heazlewood J.L.et.al.   14671022
[9] “Mapping the Arabidopsis organelle proteome.”  Dunkley T.P.J.et.al.   16618929
[10] “AtATM3 is involved in heavy metal resistance in Arabidopsis.”  Kim D.-Y.et.al.   16461380
[11] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRGSRFVRA PGLLLCRVNL QPQPKIPSFS YSLRSDYRLH NGFSNYIRRN SIRTSPVINA 
61:	FLSDNSPSPS PSPSPIRFVQ RSSMLNGRLF STSTPNPDQT TTKTKEIKTT SSDSDSAMAD 
121:	MKILRTLAGY LWMRDNPEFR FRVIAALGFL VGAKVLNVQV PFLFKLAVDW LASATGTGAS 
181:	LTTFAATNPT LLTVFATPAA VLIGYGIART GSSAFNELRT AVFSKVALRT IRSVSRKVFS 
241:	HLHDLDLRYH LSRETGGLNR IIDRGSRAIN FILSAMVFNV VPTILEISMV SGILAYKFGA 
301:	AFAWITSLSV GSYIVFTLAV TQWRTKFRKA MNKADNDAST RAIDSLINYE TVKYFNNEGY 
361:	EAEKYDQFLK KYEDAALQTQ RSLAFLNFGQ SIIFSTALST AMVLCSQGIM NGQMTVGDLV 
421:	MVNGLLFQLS LPLNFLGSVY RETIQSLVDM KSMFQLLEEK SDITNTSDAK PLVLKGGNIE 
481:	FENVHFSYLP ERKILDGISF VVPAGKSVAI VGTSGSGKST ILRMLFRFFD TDSGNIRIDG 
541:	QDIKEVRLDS LRSSIGVVPQ DTVLFNDTIF HNIHYGRLSA TEEEVYEAAR RAAIHETISN 
601:	FPDKYSTIVG ERGLKLSGGE KQRVALARTF LKSPAILLCD EATSALDSTT EAEILNALKA 
661:	LASNRTSIFI AHRLTTAMQC DEIVVLENGK VVEQGPHDEL LGKSGRYAQL WTQQNSSVDM 
721:	LDAAIKLE