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3.A.1.211.4
The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death).

Accession Number:P34358
Protein Name:ABC transporter ced-7 aka Cell death protein 7
Length:1704
Molecular Weight:191412.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

eggNOG: meNOG04495
HEGENOM: HBG381363
RefSeq: NP_001021225.1    NP_001021226.1    NP_499115.2   
Entrez Gene ID: 176352   
Pfam: PF00005   
KEGG: cel:C48B4.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008219 P:cell death
GO:0006810 P:transport

References (4)

[1] “The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.”  Wu Y.-C.et.al.   9635425
[2] “2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.”  Wilson R.et.al.   7906398
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[4] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRLRQFSLL LWKDWVLLRR NKVWTLFELI IPCLLLGPLV YLVVKNADHT SSPENIYDNF 
61:	QVKGTVEDVF LESNFIKPIY KRWCLRSDVV VGYTSKDAAA KRTVDDLMKK FAERFQSAKL 
121:	KLSVKNESSE EQLLTVLRND LPMLNETFCA INSYAAGVVF DEVDVTNKKL NYRILLGKTP 
181:	EETWHLTETS YNPYGPSSGR YSRIPSSPPY WTSAFLTFQH AIESSFLSSV QSGAPDLPIT 
241:	LRGLPEPRYK TSSVSAFIDF FPFIWAFVTF INVIHITREI AAENHAVKPY LTAMGLSTFM 
301:	FYAAHVVMAF LKFFVIFLCS IIPLTFVMEF VSPAALIVTV LMYGLGAVIF GAFVASFFNN 
361:	TNSAIKAILV AWGAMIGISY KLRPELDQIS SCFLYGLNIN GAFALAVEAI SDYMRREREL 
421:	NLTNMFNDSS LHFSLGWALV MMIVDILWMS IGALVVDHIR TSADFSLRTL FDFEAPEDDE 
481:	NQTDGVTAQN TRINEQVRNR VRRSDMEIQM NPMASTSLNP PNADSDSLLE GSTEADGARD 
541:	TARADIIVRN LVKIWSTTGE RAVDGLSLRA VRGQCSILLG HNGAGKSTTF SSIAGIIRPT 
601:	NGRITICGYD VGNEPGETRR HIGMCPQYNP LYDQLTVSEH LKLVYGLKGA REKDFKQDMK 
661:	RLLSDVKLDF KENEKAVNLS GGMKRKLCVC MALIGDSEVV LLDEPTAGMD PGARQDVQKL 
721:	VEREKANRTI LLTTHYMDEA ERLGDWVFIM SHGKLVASGT NQYLKQKFGT GYLLTVVLDH 
781:	NGDKRKMAVI LTDVCTHYVK EAERGEMHGQ QIEIILPEAR KKEFVPLFQA LEAIQDRNYR 
841:	SNVFDNMPNT LKSQLATLEM RSFGLSLNTL EQVFITIGDK VDKAIASRQN SRISHNSRNA 
901:	SEPSLKPAGY DTQSSTKSAD SYQKLMDSQA RGPEKSGVAK MVAQFISIMR KKFLYSRRNW 
961:	AQLFTQVLIP IILLGLVGSL TTLKSNNTDQ FSVRSLTPSG IEPSKVVWRF ENGTIPEEAA 
1021:	NFEKILRKSG GFEVLNYNTK NPLPNITKSL IGEMPPATIG MTMNSDNLEA LFNMRYYHVL 
1081:	PTLISMINRA RLTGTVDAEI SSGVFLYSKS TSNSNLLPSQ LIDVLLAPML ILIFAMVTST 
1141:	FVMFLIEERT CQFAHQQFLT GISPITFYSA SLIYDGILYS LICLIFLFMF LAFHWMYDHL 
1201:	AIVILFWFLY FFSSVPFIYA VSFLFQSPSK ANVLLIIWQV VISGAALLAV FLIFMIFNID 
1261:	EWLKSILVNI FMFLLPSYAF GSAIITINTY GMILPSEELM NWDHCGKNAW LMGTFGVCSF 
1321:	ALFVLLQFKF VRRFLSQVWT VRRSSHNNVQ PMMGDLPVCE SVSEERERVH RVNSQNSALV 
1381:	IKDLTKTFGR FTAVNELCLA VDQKECFGLL GVNGAGKTTT FNILTGQSFA SSGEAMIGGR 
1441:	DVTELISIGY CPQFDALMLD LTGRESLEIL AQMHGFENYK AKAELILECV GMIAHADKLV 
1501:	RFYSGGQKRK ISVGVALLAP TQMIILDEPT AGIDPKARRE VWELLLWCRE HSNSALMLTS 
1561:	HSMDECEALC SRIAVLNRGS LIAIGSSQEL KSLYGNNYTM TLSLYEPNQR DMVVQLVQTR 
1621:	LPNSVLKTTS TNKTLNLKWQ IPKEKEDCWS AKFEMVQALA KDLGVKDFIL AQSSLEETFL 
1681:	RLAGLDEDQL DTHSTVEISH STHV