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3.A.1.211.8
AbcA12 Keratinocyte lipid transporter.  Transports lipids in lamellar granules to the apical surface of granular layer keratinocytes. Extracellular lipids, including ceramide, are thought to be essential for skin barrier function. ABCA12 mutations underlie the three main types of autosomal recessive congenital ichthyoses: harlequin ichthyosis, lamellar ichthyosis and congenital ichthyosiform erythroderma. ABCA12 mutations lead to defective lipid transport via lamellar granules in the keratinocytes, resulting in malformation of the epidermal lipid barrier and ichthyosis phenotypes. Lipid transport by ABCA12 is indispensable for intact differentiation of keratinocytes (Akiyama, 2011). 

Accession Number:B9EKF0
Protein Name:Gene model 1060, (NCBI)
Length:753
Molecular Weight:88539.00
Species:Mus musculus (Mouse) [10090]
Substrate lipids, Ceramide

Cross database links:

Genevestigator: B9EKF0

References (1)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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FASTA formatted sequence
1:	MNPSGTIGVL EQNGEEHLAT PILGPSVHSD NPQERIQARR LRIAARQEAR RREALGEYLD 
61:	GKKESEEEQS KSYKQKEESR LKLTKLLLCG TELVTNIQVA ADVREIHRRV EEEETKRQRL 
121:	EKLENEVKTS QDKFDEITAK WEEGRRKRIP QELWEMLNSQ QVHCAELIED KNKLANELQQ 
181:	ELKIKDDQYV KDLKKQSEDI TLILERMEEQ VKNVMKNFRQ ELIHIEKAFE SERQELLSSN 
241:	KKKWERALQA HNAKELEYLT NRMKKVEDYE KQLNKQRVWD CEEYNTIKIK LEQDVQILEQ 
301:	QLQQMKATYQ LNQEKLEYNF QVLKKRDEES TVIKSQQKRK LNRLHDVVNN LRTKYTKQIR 
361:	QFQDDNQSLT SDYKRLVTQF KDLQKALRHF IIIDEEKFRE IWLMNEAEAK ELAQRAFDVD 
421:	RIIHSQHLGL PWNMPDLWFL NNVGPISLQQ QKSVTQILEE LLLQTEDEAT EAAMSEDEDY 
481:	MDLPNQISAK TTTKVLMLLC DESGFLIESK LLSLLHPLEK SECYLLRLDA IFSALAIEDE 
541:	DDLYKLVNFF LRYRAHRLSS AQASSSIHSN MERTSLMSAL ERLSLMSQTD KGSMVSKSDQ 
601:	EPTEQEDEQE GDNASLSSRE LEEQEDLSSP RFIHPNDVLK ILEAFVTGLK KPKDAQPVLK 
661:	LKKETRDNSK DTEYWESLAA VIPFFKQNLW DALYKALEKY YLVLTERAKL LMENESLEQQ 
721:	NAEMQSLLQQ YLQAKVNTEL QIPPTQGFRM PSK