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3.A.1.212.1
The mitochondrial peptide exporter, Mdl1p (exports peptides of 6-21 amino acyl residues from the mitochondrial matrix as well as degradation products of misassembled respiratory chain complexes) (Janas et al., 2003; van der Does et al., 2006; Gompf et al., 2007). A leaderless Mdl1p targets to the ER membrane instead of to the mitochondria (Gompf et al., 2007).

Accession Number:P33310
Protein Name:MDL1 aka Mdl1p aka YLR188W aka L9470.3
Length:695
Molecular Weight:75950.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

Genevestigator: P33310
eggNOG: fuNOG07753
HEGENOM: HBG758042
RefSeq: NP_013289.1   
Entrez Gene ID: 850885   
Pfam: PF00664    PF00005   
KEGG: sce:YLR188W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005524 F:ATP binding
GO:0015421 F:oligopeptide-transporting ATPase activity
GO:0006857 P:oligopeptide transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily.”  Dean M.C.et.al.   7912468
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[3] “Role of the ABC transporter Mdl1 in peptide export from mitochondria.”  Young L.et.al.   11251115
[4] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “The proteome of Saccharomyces cerevisiae mitochondria.”  Sickmann A.et.al.   14576278

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIVRMIRLCK GPKLLRSQFA SASALYSTKS LFKPPMYQKA EINLIIPHRK HFLLRSIRLQ 
61:	SDIAQGKKST KPTLKLSNAN SKSSGFKDIK RLFVLSKPES KYIGLALLLI LISSSVSMAV 
121:	PSVIGKLLDL ASESDGEDEE GSKSNKLYGF TKKQFFTALG AVFIIGAVAN ASRIIILKVT 
181:	GERLVARLRT RTMKAALDQD ATFLDTNRVG DLISRLSSDA SIVAKSVTQN VSDGTRAIIQ 
241:	GFVGFGMMSF LSWKLTCVMM ILAPPLGAMA LIYGRKIRNL SRQLQTSVGG LTKVAEEQLN 
301:	ATRTIQAYGG EKNEVRRYAK EVRNVFHIGL KEAVTSGLFF GSTGLVGNTA MLSLLLVGTS 
361:	MIQSGSMTVG ELSSFMMYAV YTGSSLFGLS SFYSELMKGA GAAARVFELN DRKPLIRPTI 
421:	GKDPVSLAQK PIVFKNVSFT YPTRPKHQIF KDLNITIKPG EHVCAVGPSG SGKSTIASLL 
481:	LRYYDVNSGS IEFGDEDIRN FNLRKYRRLI GYVQQEPLLF NGTILDNILY CIPPEIAEQD 
541:	DRIRRAIGKA NCTKFLANFP DGLQTMVGAR GAQLSGGQKQ RIALARAFLL DPAVLILDEA 
601:	TSALDSQSEE IVAKNLQRRV ERGFTTISIA HRLSTIKHST RVIVLGKHGS VVETGSFRDL 
661:	IAIPNSELNA LLAEQQDEEG KGGVIDLDNS VAREV