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3.A.10.1.7
K+-activated, H+-transporting pyrophosphatase, H+-PPase (Huang et al. 2013).  Trp-602 is a crucial residue that may stabilize the structure of the catalytic region (Chen et al. 2014).

Accession Number:Q898Q9
Protein Name:Putative K(+)-stimulated pyrophosphate-energized sodium pump
Length:673
Molecular Weight:69282.00
Species:Clostridium tetani [1513]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

HEGENOM: HBG593668
Entrez Gene ID: 1059962   
Pfam: PF03030   
KEGG: ctc:CTC00383   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009678 F:hydrogen-translocating pyrophosphatase activity
GO:0004427 F:inorganic diphosphatase activity
GO:0015992 P:proton transport
GO:0006814 P:sodium ion transport

References (1)

[1] “The genome sequence of Clostridium tetani, the causative agent of tetanus disease.”  Brueggemann H.et.al.   12552129

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESFIVYSVL AGVIALIFAF MLSSFISKES AGNERMQEIA GHIHDGAMAF LKTEYKYLTG 
61:	FIVIVTVILA IFVGWQTAAC FILGAIFSIF AGYFGMNVAT KANVRTAEAA RHSQGKALNI 
121:	AFSGGAVMGM SVVGLGVVGI GIMYYIFGGN MEFVTGFGLG ASSIALFARV GGGIYTKAAD 
181:	VGADLVGKVE AGIPEDDPRN PAVIADNVGD NVGDVAGMGA DLFESYVGSI ISALTLGTVV 
241:	YANKEGVMFP LILSSIGIVA SIIGILFSRK SKAKDPQKAL NTGTYIGGII VIVSAAILSN 
301:	TIFGNLKAFF AVASGLVVGM IIGKITEMYT SDAYSSVQKI ANQSETGPAT TIISGLAVGM 
361:	YSTLWPIVLI SIGVLVSFFV MGGGSNAMVG LYGISLAAVG MLSTTGLTVA VDAYGPIADN 
421:	AGGIAEMSEL PHEVREITDK LDSVGNTTAA IGKGFAIGSA ALTALSLFAS YAQATELESI 
481:	DILNTVTLVG LFIGAMLPFL FGALTMESVG KAANEMIEEV RRQFKTIPGI MEGKATPDYK 
541:	KCVDISTAAA IREMILPGVL AIVVPVAMGL LLGKEALGGL LAGALVSGVL VGILMSNAGG 
601:	AWDNAKKYIE GGAHGGKGSE AHKAAVVGDT VGDPFKDTSG PSMNILIKLM TIVSLVFAPV 
661:	VLQYGGILLN LIK