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3.A.10.2.2
H+-translocating pyrophosphatase. This protein has a basic 16 TMS topology with several large cytoplasmic loops containing functional motifs as well as one or two C-terminal TMS(s) (Mimura et al., 2004).  Residues involved in energy coupling and proton transport have been identified (Hirono et al. 2007).

Accession Number:Q6BCL0
Protein Name:H+-pyrophosphatase
Length:794
Molecular Weight:80590.00
Species:Streptomyces coelicolor [1902]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

Pfam: PF03030   

Gene Ontology

GO:0016020 C:membrane
GO:0009678 F:hydrogen-translocating pyrophosphatase acti...
GO:0004427 F:inorganic diphosphatase activity
GO:0015992 P:proton transport

References (1)

[1] “Membrane topology of the H+-pyrophosphatase of Streptomyces coelicolor determined by cysteine-scanning mutagenesis.”  Mimura H.et.al.   15187077

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAELPTSHLA AAVLTDGNRA LVAVIAVVAL AALVLAGVLV RQVLAAGEGT DSMKKIAAAV 
61:	QEGANAYLAR QLRTLGVFAV VVFFLLMLLP ADDWNQRAGR SIFFLIGAAF SAATGYIGMW 
121:	LAVRSNVRVA AAAREATPAP GEPEKDLALV SHKATKIAFR TGGVVGMFTV GLGLLGACCV 
181:	VLVYAADAPK VLEGFGLGAA LIAMFMRVGG GIFTKAADVG ADLVGKVEQG IPEDDPRNAA 
241:	TIADNVGDNV GDCAGMAADL FESYAVTLVA ALILGKVAFG DSGLAFPLLV PAIGVLTAMI 
301:	GIFAVAPRRS DRSGMSAINR GFFISAVISL VLVAVAVFVY LPGKYADLDG VTDAAIAGKS 
361:	GDPRILALVA VAIGIVLAAL IQQLTGYFTE TTRRPVKDIG KSSLTGPATV VLAGISLGLE 
421:	SAVYTALLIG LGVYGAFLLG GTSIMLALFA VALAGTGLLT TVGVIVAMDT FGPVSDNAQG 
481:	IAEMSGDVEG AGAQVLTDLD AVGNTTKAIT KGIAIATAVL AAAALFGSYR DAITTGAADV 
541:	GEKLSGEGAP MTLMMDISQP NNLVGLIAGA AVVFLFSGLA INAVSRSAGA VVYEVRRQFR 
601:	ERPGIMDYSE KPEYGKVVDI CTRDALRELA TPGLLAVMAP IFIGFTLGVG ALGAFLAGAI 
661:	GAGTLMAVFL ANSGGSWDNA KKLVEDGHHG GKGSEAHAAT VIGDTVGDPF KDTAGPAINP 
721:	LLKVMNLVAL LIAPAVIKFS YGADKSVVVR VLIAVVAFAV IAAAVYVSKR RGIAMGDEDD 
781:	ADPEPKSADP AVVS