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3.A.10.2.3
Vacuolar Ca2+-hypersenstive, K+-insensitive, H+ -translocating, inorganic pyrophosphatase, AVP2 (Drozdowicz et al., 2000)

Accession Number:Q56ZN6
Protein Name:Pyrophosphate-energized membrane proton pump 2 aka AVP2
Length:802
Molecular Weight:85133.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

Genevestigator: Q56ZN6
eggNOG: euNOG15486
HEGENOM: HBG593668
RefSeq: NP_001117619.1    NP_565195.1   
Entrez Gene ID: 844231   
Pfam: PF03030   
KEGG: ath:AT1G78920   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005773 C:vacuole
GO:0009678 F:hydrogen-translocating pyrophosphatase acti...
GO:0004427 F:inorganic diphosphatase activity
GO:0015992 P:proton transport

References (5)

[1] “AVP2, a sequence-divergent, K(+)-insensitive H(+)-translocating inorganic pyrophosphatase from Arabidopsis.”  Drozdowicz Y.M.et.al.   10806252
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana.”  Shimaoka T.et.al.   15215502
[5] “Novel type Arabidopsis thaliana H(+)-PPase is localized to the Golgi apparatus.”  Mitsuda N.et.al.   11163790

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMMDEDVEQA SLMSFNDRPR AFPNMRSKTY SPLIFRIIRK LNVRVLSIIL LFCFGAIFYM 
61:	GASTSPIIVF VFTVCIISFL LSIYLTKWVL AKDEGPPEMV EISDAIRDGA EGFFRTQYST 
121:	ISKMAILLAF VILCIYLFRS LTPQQEAAGL GRAMSAYITV AAFLLGALCS GIAGYVGMWV 
181:	SVRANVRVSS AARRSAREAL QIAVRAGGFS ALVVVGMAVI GIAILYSTFY VWLGVGSPGS 
241:	MNVTDLPLLL VGYGFGASFV ALFAQLGGGI YTKGADVGAD LVGKVEQGIP EDDPRNPAVI 
301:	ADLVGDNVGD CAARGADLFE SIAAEIISAM ILGGTMAKKC KIEDPSGFIL FPLVVHSFDL 
361:	IISSIGILSI KGTRDASVKS PVEDPMAVLQ KGYSLTIILA VITFGASTRW LLYTEQAPSA 
421:	WFNFALCGLV GIITAYIFVW ISKYYTDYKH EPVRTLALAS STGHGTNIIA GVSLGLESTA 
481:	LPVLTISVAI ISAYWLGNTS GLVDENGIPT GGLFGTAVAT MGMLSTAAYV LTMDMFGPIA 
541:	DNAGGIVEMS QQPESVREIT DLLDAVGNTT KATTKGFAIG SAALASFLLF SAYMDEVSAF 
601:	ANVSFKEVDI AIPEVFVGGL LGAMLIFLFS AWACAAVGRT AQEVVNEVRR QFIERPGIME 
661:	YKEKPDYSRC VAIVASAALR EMIKPGALAI ASPIVVGLVF RILGYYTGQP LLGAKVVASM 
721:	LMFATVCGIL MALFLNTAGG AWDNAKKYIE TGALGGKGSE AHKAAVTGDT VGDPFKDTAG 
781:	PSIHVLIKML ATITLVMAPV FL