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3.A.10.2.4
Na+ -translocating PPase (Malinen et al., 2007)

Accession Number:Q8PYZ7
Protein Name:Pyrophosphate-energized proton pump 2 aka HppA2
Length:671
Molecular Weight:69062.00
Species:Methanosarcina mazei (Methanosarcina frisia) [2209]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

HEGENOM: HBG593668
RefSeq: NP_632725.1   
Entrez Gene ID: 1479043   
Pfam: PF03030   
BioCyc: MMAZ192952:MM0701-MONOMER   
KEGG: mma:MM_0701   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009678 F:hydrogen-translocating pyrophosphatase acti...
GO:0004427 F:inorganic diphosphatase activity
GO:0000287 F:magnesium ion binding
GO:0015992 P:proton transport

References (1)

[1] “The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.”  Deppenmeier U.et.al.   12125824

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERLIFTAPL AGLISLTFAA FFAKSILKED AGNKRMKEIA EAIKEGSTAY MKRQYRTIAV 
61:	VSVIISLLIL FLLDEGLKIA AGFLAGAISS AAAGYIGMSI SVRANVRTAS AASGGAGKAL 
121:	KIAFRGGAVT GLAVIGLALL GTSSLYILYG DADLVVGFGF GASLISLFAR AGGGIFTKAA 
181:	DVGADLVGKI EAGIPEDDPR NPAVIADNVG DNVGDCAGMG ADLFETYVVT SLAAMLLGSL 
241:	IIGTYKNAVL YPLMLGSAAI FASIISVFFV KVEKEGKVMS ALYRGVGGST VLSLIAFYYI 
301:	TGFLMGDSRF FYVTVAGVVI TVLMVIVTEY YTSKSCRPVK TIAVSSETGA ATNIISGLSA 
361:	GFESTLVPAV VIAAGILVSY FIVGGSADPG TGLYGIAIAS VAMLSTAGMI VALDSYGPIT 
421:	DNAGGIAQMA NLPAQVRKVT DELDSVGNTT KAVTKGYAIG STALGALALF ADYRNKVSLE 
481:	SQSISLDSPV VLSGILLGAV LPFLFSAVMM SAVGKAAFEV VNEVRRQFRE IPGIMEGTAK 
541:	PEYGRCVDIV TKAALHDMAM PGFLAVIIPL LTGFFLGPEA LAGLLTGLIV VGFMLALMMD 
601:	NGGGAWDNAK KLIEDGYYGG KGSEAHRAAV VGDTVGDPFK DTAGPALNSL IKVVNMVAIL 
661:	FSPLIIGGGF L