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3.A.10.3.1
H+-translocating pyrophosphatase

Accession Number:Q8ZWI8
Protein Name:Pyrophosphate-energized proton pump
Length:721
Molecular Weight:75394.00
Species: [13773]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

HEGENOM: HBG593668
RefSeq: NP_559532.1   
Entrez Gene ID: 1465965   
Pfam: PF03030   
BioCyc: PAER178306:PAE1771-MONOMER   
KEGG: pai:PAE1771   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009678 F:hydrogen-translocating pyrophosphatase acti...
GO:0004427 F:inorganic diphosphatase activity
GO:0000287 F:magnesium ion binding
GO:0015992 P:proton transport

References (2)

[1] “A thermostable vacuolar-type membrane pyrophosphatase from the archaeon Pyrobaculum aerophilum: implications for the origins of pyrophosphate-energized pumps.”  Drozdowicz Y.M.et.al.   10556526
[2] “Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.”  Fitz-Gibbon S.T.et.al.   11792869

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNMISYALLG VILGISGVIY AVYLAVWVLR QDPGNEKMRF ISQAIATGAR AYLFRQYRTL 
61:	AVLLVILAVL ILVAIDMPRR TFGLTALAFI VGALGSMLAG YLGMYVTTRS ASRVAQAAAT 
121:	GGMGKALLVS WRAGAVMGLS LASIALLLIS GFYLVFRSVL PDDWAVPLVA LGFGASLVTL 
181:	FMRVGGGIYT KAADLGADLV GKVEAGIPED DPRNPGVIAD NVGDNVGDVA GMAADVYESY 
241:	IVTVTAAIFL AAILGLPTQF IEAIILFAAL ALVATFAGVN LLKTTGVKHP LSSISLAIYA 
301:	TIGLSVVLFF IGAFTLGLDS TKALALAATT SLGAVIAPLI VKITDYYTSY NYGPVRKIAE 
361:	QAKISPATVI ITGYGVGLMS AIPVIAVIVA VLGISYMIGY YTVPVSGFGE LSKYLAGIFG 
421:	TAMASVGLLV VAGIIITADS YGPVSDNAGG VVEMAGLPDE VREITDVLDS VGNTTKATTK 
481:	GYAIASAALA ALVLFIALIF EIVYSASKIL GKGIVDMISE SLSGLQLINA NVLIGAFLGV 
541:	ALVYFFSSRT LEAVGRTAME IVEEIRRQFR EKPGILEWKE QPDYARVVDI ATRRALGEFL 
601:	IPGLAAIVLP LITGLLLGWN ALAGLIMGAI VAGVPRALLM ANAGGAWDNA KKYIEIQGLK 
661:	KTEMHKAAVI GDTVGDPMKD TVGPSLNPLI KVLNTLSVVF TYVIVSTNIA LGIWPSGLLP 
721:	F